Error awareness and salience processing in the oddball task: shared neural mechanisms.
Error awareness and salience processing in the oddball task: shared neural mechanisms.
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DOI：
10.3389/fnhum.2012.00246
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发表时间：
2012
影响因子：
2.9
通讯作者：
Ridderinkhof KR
中科院分区：
文献类型：
--
作者：
Harsay HA;Spaan M;Wijnen JG;Ridderinkhof KR
大量研究表明，我们意识到错误和处理动机突出事件的方式有相似之处。然而，没有证据表明存在共同的神经机制。一项涉及错误意识和显著性处理的大脑区域的研究尚未被报道。虽然对动机突出事件的神经反应通常是在古怪任务中较长时间的目标到目标间隔后的目标检测过程中研究的，并且涉及广泛的脑岛-丘脑-皮层网络，但错误意识最近与最突出的是，与前脑岛皮层联系在一起。在这里，我们通过测试两种不同任务设置下的激活重叠来探讨错误感知的前脑岛激活是否与显著性处理有关。使用受试者内部设计，我们显示了在反眼跳任务的意识错误期间和在较长的目标到目标间隔后的目标检测期间，在一个奇怪的任务中，六个主要脑区域的激活重叠：前岛、前扣带、补充运动区、丘脑、脑干和顶叶。受试者内部分析表明，脑岛同时参与错误意识和显著性处理，且前脑岛比后脑岛更多地参与这两个过程。对同一受试者的活动簇进行细粒度空间模式重叠分析的结果表明，即使前脑岛的错误感知和显著性处理都被激活，这两种类型的处理也可能倾向于在细粒度空间水平上激活不相同的神经系统。总之，这些结果表明在两种不同的任务设置中存在类似的功能现象。错误感知和显著性处理共享一个功能解剖结构，在前脑岛有分区域背侧和腹侧特化的趋势。
A body of work suggests similarities in the way we become aware of an error and process motivationally salient events. Yet, evidence for a shared neural mechanism has not been provided. A within subject investigation of the brain regions involved in error awareness and salience processing has not been reported. While the neural response to motivationally salient events is classically studied during target detection after longer target-to-target intervals in an oddball task and engages a widespread insula-thalamo-cortical brain network, error awareness has recently been linked to, most prominently, anterior insula cortex. Here we explore whether the anterior insula activation for error awareness is related to salience processing, by testing for activation overlap in subjects undergoing two different task settings. Using a within subjects design, we show activation overlap in six major brain areas during aware errors in an antisaccade task and during target detection after longer target-to-target intervals in an oddball task: anterior insula, anterior cingulate, supplementary motor area, thalamus, brainstem, and parietal lobe. Within subject analyses shows that the insula is engaged in both error awareness and the processing of salience, and that the anterior insula is more involved in both processes than the posterior insula. The results of a fine-grained spatial pattern overlap analysis between active clusters in the same subjects indicates that even if the anterior insula is activated for both error awareness and salience processing, the two types of processes might tend to activate non-identical neural ensembles on a finer-grained spatial level. Together, these outcomes suggest a similar functional phenomenon in the two different task settings. Error awareness and salience processing share a functional anatomy, with a tendency toward subregional dorsal and ventral specialization within the anterior insula.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
2.5
作者：
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影响因子：
3
作者：
Critchley, Hugo D.
通讯作者：
Critchley, Hugo D.
DOI：
10.1016/0013-4694(95)98475-n
发表时间：
1995-04-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HALGREN, E;BAUDENA, P;BIRABEN, A
通讯作者：
BIRABEN, A
影响因子：
2.5
作者：
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通讯作者：
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