ER-mediated control for abundance, quality, and signaling of transmembrane immune receptors in plants.
ER-mediated control for abundance, quality, and signaling of transmembrane immune receptors in plants.
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ER介导的控制植物中跨膜免疫受体的丰度，质量和信号传导。
DOI：
10.3389/fpls.2014.00065
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发表时间：
2014
影响因子：
5.6
通讯作者：
Saijo Y
中科院分区：
文献类型：
--
作者：
Tintor N;Saijo Y
植物通过细胞表面和细胞内的免疫受体识别广泛的微生物。跨膜模式识别受体(PRRs)在识别微生物或异常细胞状态的同源配体时启动免疫反应，分别被称为微生物相关分子模式或危险相关分子模式(DAMP)，模式触发的免疫提供了第一道防线，限制了适应性和非适应性病原体的入侵和繁殖。受体激酶(RKs)和具有胞外富含亮氨酸重复序列或赖氨酸基序(LysM)结构域的受体样蛋白(RLP)被广泛用作PRRs。这些受体的胞外区的正确折叠是在内质网(ER)的质量控制(QC)下进行的，因此这是植物免疫中的关键步骤。遗传和结构研究表明，ERQC不仅调节跨膜受体的丰度和质量，还影响受体下游多分支通路之间的信号分选。然而，ERQC功能障碍也可以通过细胞死亡和抑制信号通路来积极刺激植物免疫。
Plants recognize a wide range of microbes with cell-surface and intracellular immune receptors. Transmembrane pattern recognition receptors (PRRs) initiate immune responses upon recognition of cognate ligands characteristic of microbes or aberrant cellular states, designated microbe-associated molecular patterns or danger-associated molecular patterns (DAMPs), respectively.Pattern-triggered immunity provides a first line of defense that restricts the invasion and propagation of both adapted and non-adapted pathogens. Receptor kinases (RKs) and receptor-like proteins (RLPs) with an extracellular leucine-rich repeat or lysine-motif (LysM) domain are extensively used as PRRs. The correct folding of the extracellular domain of these receptors is under quality control (QC) in the endoplasmic reticulum (ER), which thus provides a critical step in plant immunity. Genetic and structural insight suggests that ERQC regulates not only the abundance and quality of transmembrane receptors but also affects signal sorting between multi-branched pathways downstream of the receptor. However, ERQC dysfunction can also positively stimulate plant immunity, possibly through cell death and DAMP signaling pathways.
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