Biological Fixation of Bioactive Bone Cement in Vertebroplasty: The First Clinical Investigation of Borosilicate Glass (BSG) Reinforced PMMA Bone Cement.
Biological Fixation of Bioactive Bone Cement in Vertebroplasty: The First Clinical Investigation of Borosilicate Glass (BSG) Reinforced PMMA Bone Cement.
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椎体成形术中生物活性骨水泥的生物固定：硼硅酸盐玻璃 (BSG) 增强 PMMA 骨水泥的首次临床研究。
DOI：
10.1021/acsami.2c15250
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发表时间：
2022-11
影响因子：
9.5
通讯作者：
Haobo Pan
中科院分区：
文献类型：
--
作者：
Hao Zhang;Yinglin Cu;Xianglong Zhuo;Jua Kim;Honglong Li;Shuaijie Li;Hongsheng Yang;Kun Su;Chunyu Liu;Pengfei Tian;Xian Li;Li Li;Deping Wang;Limin Zhao;Jianyun Wang;Xu Cui;Bing Li;Haobo Pan
PMMA骨水泥以其高的机械强度和良好的可注射性被临床应用于椎体成形术数十年。然而，骨与PMMA之间的界面是脆弱的，更容易在原位再次断裂，这是因为PMMA缺乏来自宿主骨的适当的生物反应，最少的骨整合和致密的纤维组织形成。在这里，我们通过将硼硅酸盐玻璃(BSG)与[BO_3]和[SiO_4]双玻璃网络相结合来修饰PMMA，这种双玻璃网络可以自发地调节免疫和成骨。特别是，BSG改性的PMMA骨水泥(简称BSG/PMMA骨水泥)提供了一个碱性微环境，可以自发地平衡破骨细胞和成骨细胞之间的活动。此外，从BSG中释放的微量元素促进了成骨，从而加强了宿主骨与种植体之间的界面。本研究报告了首例BSG/PMMA植入三个月后的临床病例，应用双能CT发现PMMA周围有磷灰石成核，而不是纤维组织，表明生物界面已经形成。因此，BSG/PMMA作为一种生物材料在椎体成形术中具有很好的应用前景，通过改善宿主骨的生物反应，克服了PMMA的缺点。
PMMA bone cement has been clinically used for decades in vertebroplasty due to its high mechanical strength and satisfactory injectability. However, the interface between bone and PMMA is fragile and more prone to refracture in situ because PMMA lacks a proper biological response from the host bone with minimal bone integration and dense fibrous tissue formation. Here, we modified PMMA by incoporating borosilicate glass (BSG) with a dual glass network of [BO3] and [SiO4], which spontaneously modulates immunity and osteogenesis. In particular, the BSG modified PMMA bone cement (abbreviated as BSG/PMMA cement) provided an alkaline microenvironment that spontaneously balanced the activities between osteoclasts and osteoblasts. Furthermore, the trace elements released from the BSGs enhanced the osteogenesis to strengthen the interface between the host bone and the implant. This study shows the first clinical case after implantation of BSG/PMMA for three months using the dual-energy CT, which found apatite nucleation around PMMA instead of fibrous tissues, indicating the biological interface was formed. Therefore, BSG/PMMA is promising as a biomaterial in vertebroplasty, overcoming the drawback of PMMA by improving the biological response from the host bone.
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影响因子：
9.9
作者：
Gomez-Cerezo, N.;Casarrubios, L.;Portoles, M. T.
通讯作者：
Portoles, M. T.
影响因子：
3.9
作者：
Pan, H. B.;Zhao, X. L.;Chang, J.
通讯作者：
Chang, J.
DOI：
10.1002/jbm.b.33428
发表时间：
2016-04
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Changyun Quan;Yong Tang;Zhenzhen Liu;Minyu Rao;Wei Zhang;Peiqing Liang;Nan Wu;Chao Zhang;Huiyong Shen;Qing Jiang
通讯作者：
Changyun Quan;Yong Tang;Zhenzhen Liu;Minyu Rao;Wei Zhang;Peiqing Liang;Nan Wu;Chao Zhang;Huiyong Shen;Qing Jiang
影响因子：
5.8
作者：
Cheng, Delin;Liang, Qingfei;Ruan, Changshun
通讯作者：
Ruan, Changshun
透明质酸通过加速成骨表达促进磷酸钙骨水泥的骨修复作用
影响因子：
18.9
作者：
Cui X;Huang C;Chen Z;Zhang M;Liu C;Su K;Wang J;Li L;Wang R;Li B;Chen D;Ruan C;Wang D;Lu WW;Pan H
通讯作者：
Pan H