Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study.
Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study.
复制标题
DOI：
10.1016/j.neuroimage.2009.11.053
复制
发表时间：
2010-04-01
期刊：
影响因子：
5.7
通讯作者：
Horwitz, Barry
中科院分区：
文献类型：
--
作者：
Smith, Jason F.;Alexander, Gene E.;Chen, Kewei;Husain, Fatima T.;Kim, Jieun;Pajor, Nathan;Horwitz, Barry
以前，一个系统级记忆巩固的标准理论被发展来描述记忆回忆如何独立于内侧时间记忆系统。最近，一种扩展巩固理论被提出，该理论预测了区域神经活动和区域间功能连通性的七种变化。利用与关联记忆任务相关的纵向事件功能磁共振成像，我们同时测试了所有预测，并在次试验时间分辨率下测试了关联记忆回忆的巩固相关变化，分别分析了每个试验的线索、延迟和目标期。结果与理论预测一致，但也得到了两个不一致的结果。特别是，正如预测的那样，与回忆相关的延迟期活动随着巩固而减少，而视觉线索活动则随着巩固记忆而增加。虽然我们的研究在很大程度上支持了记忆巩固的扩展理论，但这些结果表明，扩展理论需要进一步完善，内侧时间记忆系统在联想记忆回忆中具有多重的、时间上不同的作用。在亚试验时间分辨率下的神经成像分析，如本文所使用的，可能进一步阐明海马复合体在记忆巩固中的作用。
Previously, a standard theory of systems level memory consolidation was developed to describe how memory recall becomes independent of the medial temporal memory system. More recently, an extended consolidation theory was proposed that predicts seven changes in regional neural activity and inter-regional functional connectivity. Using longitudinal event related functional magnetic resonance imaging of an associate memory task, we simultaneously tested all predictions and additionally tested for consolidation related changes in recall of associate memories at a sub-trial temporal resolution, analyzing cue, delay and target periods of each trial separately. Results consistent with the theoretical predictions were observed though two inconsistent results were also obtained. In particular, while recall-related delay period activity decreased with consolidation as predicted, visual cue activity increased for consolidated memories. Though the extended theory of memory consolidation is largely supported by our study, these results suggest the extended theory needs further refinement and the medial temporal memory system has multiple, temporally distinct roles in associate memory recall. Neuroimaging analysis at a sub-trial temporal resolution, as used here, may further clarify the role of the hippocampal complex in memory consolidation.
登录
查看更多内容
影响因子：
5.7
作者：
Friston, KJ;Zarahn, E;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.5
作者：
Bosshardt, S;Degonda, N;Henke, K
通讯作者：
Henke, K
影响因子：
3.4
作者：
EACOTT, MJ;GAFFAN, D
通讯作者：
GAFFAN, D
影响因子：
1.7
作者：
Baddeley, A
通讯作者：
Baddeley, A
影响因子：
3.5
作者：
Kensinger, EA;Ullman, MT;Corkin, S
通讯作者：
Corkin, S