Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.
Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types.
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DOI：
10.1016/j.dib.2021.107014
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发表时间：
2021-06
期刊：
影响因子：
1.2
通讯作者：
Zheng T
中科院分区：
文献类型：
--
作者：
Cheng Z;Zhang X;Bassig B;Hauser R;Holford TR;Zheng E;Shi D;Zhu Y;Schwartz SM;Chen C;Shi K;Yang B;Qian Z;Boyle P;Zheng T
在一项以人群为基础的睾丸生殖细胞肿瘤（TGCT）病例对照研究中，我们报告了血清Wolff第1组（潜在雌激素）多氯联苯（PCB）水平与TGCT风险之间的强正相关性，并且观察到的相关性在腺瘤和非腺瘤中相似。虽然观察到的特定关联之间的TGCT和沃尔夫的第1组多氯联苯不能很容易地解释的偏见或混淆，一个问题仍然可以问，即，可以多氯联苯和TGCT之间的关系不同的诊断年龄？多氯联苯往往具有生物累积性，氯化程度较高的多氯联苯同系物往往具有较长的半衰期。据报告，多氯联苯同系物的半衰期从多氯联苯-28的4.6年到多氯联苯-156的41.0年不等。早期研究发现，重多氯联苯同系物的半衰期（17.8年）大约是轻多氯联苯（9.6年）的两倍。因此，在20岁和55岁人群中测得的相同多氯联苯浓度不太可能代表相同的多氯联苯终生接触或接触类型。在这项分析中，我们根据诊断TGCT的中位年龄对数据进行分层，并进一步根据TGCT的组织学类型（腺瘤与非腺瘤）进行分层，以探讨与PCB暴露相关的TGCT风险是否因年龄而异。
In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4.6 years for PCB-28 to 41.0 years for PCB-156. The half-life for the heavy PCB congeners (17.8 years) was found to be approximately twice that for the light PCBs (9.6 years) in early studies. Therefore, the same PCB concentration measured in a 20-year-old vs. a 55-year-old is unlikely to represent the same lifetime PCB exposure or type of PCB exposure. In this analysis, we stratified the data by median age of diagnosis of TGCT and further stratified by histologic type of TGCT (seminoma vs non-seminoma) to explore if the risk of TGCT associated with PCB exposures differs by age.
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影响因子：
8.9
作者：
Cheng, Zhiyuan;Zhang, Xichi;Zheng, Tongzhang
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1038/jes.2010.3
发表时间：
2011-05-01
影响因子：
4.5
作者：
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影响因子：
3.9
作者：
Greene MH;Kratz CP;Mai PL;Mueller C;Peters JA;Bratslavsky G;Ling A;Choyke PM;Premkumar A;Bracci J;Watkins RJ;McMaster ML;Korde LA
通讯作者：
Korde LA