Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents.
Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents.
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DOI：
10.1016/j.bbi.2022.06.014
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发表时间：
2022-10
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--
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中科院分区：
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对成人的研究表明，较高的外周炎症与威胁相关的杏仁核活动增加和皮质杏仁核连接减少有关。然而，在青少年中的研究有限，考虑到青春期皮质杏仁核回路发生的主要发育变化，这是惊人的。在这项研究中，我们研究了周围炎症和杏仁核活动之间的关联，并在社区样本的青少年情绪面孔的连接。参与者包括88名12至15岁的青少年，他们提供血液样本并接受功能磁共振成像扫描，同时完成面部和形状匹配任务，包括恐惧，愤怒和快乐的面孔。测定血液样本中的白细胞介素-6（IL-6）、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）;由于IL-6和CRP具有高度相关性，因此将其合并为复合物，并单独分析TNF-α。结果表明，相对于形状匹配，较高的TNF-α，而不是IL-6和CRP的复合物，与威胁（恐惧和愤怒）面孔和快乐面孔的杏仁核活性增加有关。全脑分析还确定了TNF-α与杏仁核以外区域的愤怒和快乐面孔的神经活动之间的联系。心理生理相互作用分析表明，在愤怒和恐惧的面孔>形状期间，较高的TNF-α与双侧杏仁核与左侧楔叶、右侧楔叶/距裂/楔前叶和左侧缘上回/顶下回的连接性降低有关，而较高的IL-6/CRP与双侧杏仁核与右侧中央后回和右侧楔前叶的连接性降低有关。结果表明，外周炎症与杏仁核活动增加，情绪化的脸刺激和减少杏仁核连接枕部和顶叶区域。这些发现增强了我们对外周炎症与情绪面部神经反应之间关联的理解，这可能会为针对青少年炎症的干预措施的发展提供信息。
Research in adults suggests that higher peripheral inflammation is associated with increased threat-related amygdala activity and reduced cortico-amygdala connectivity. However, there is limited research in adolescents, which is striking given the major developmental changes that occur in cortico-amygdala circuitry during adolescence. In this study, we examine the association between peripheral inflammation and amygdala activity and connectivity to emotional faces in a community sample of adolescents. Participants included 88 adolescents 12 to 15 years old who provided a blood sample and underwent fMRI scanning while completing a face and shape matching task that included fearful, angry, and happy faces. Blood samples were assayed for interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α); IL-6 and CRP were combined into a composite due to their high correlation and TNF-α was analyzed separately. Results indicated that higher TNF-α, but not the composite of IL-6 and CRP, was associated with increased amygdala activity to threatening (fearful and angry) faces and to happy faces, relative to shape matching. Whole-brain analyses also identified associations between TNF-α and neural activity to angry and happy faces in regions outside of the amygdala. Psychophysiological interaction analysis indicated that higher TNF-α was associated with reduced bilateral amygdala connectivity to the left cuneus, right cuneus/calcarine fissure/precuneus, and left supramarginal gyrus/inferior parietal gyrus during angry and fearful faces > shapes and higher IL-6/CRP was associated with reduced bilateral amygdala connectivity to the right postcentral gyrus and right precuneus. Results suggest that peripheral inflammation is associated with increased amygdala activity to emotional face stimuli and reduced amygdala connectivity with occipital and parietal regions. These findings enhance our understanding of the association between peripheral inflammation and neural response to emotional faces, which could inform the development of interventions targeting inflammation for adolescents.
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