Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility.
Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility.
复制标题
原发性和继发性不孕夫妇的男性性传播感染与精液质量的关系
DOI：
10.4103/aja202164
复制
发表时间：
2022-05
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在比较原发性和继发性不育夫妇中男性的性传播感染（STI）患病率和精液质量。从133名要求生育力评估的男性中收集精液样本。泌尿道支原体感染。(UU)采用PCR方法检测人型支原体（MH）、生殖支原体（MG）、沙眼衣原体（CT）、淋病奈瑟菌（NG）和单纯疱疹病毒2型（HSV-2）。原发性不孕夫妇男性STI患病率高于继发性不孕夫妇男性（39.7%vs21.7%，P = 0.03）。原发性不育夫妇和继发性不育夫妇中UU的检出率分别为28.8%和13.3%。原发性不孕夫妇的男性比继发性不孕夫妇的男性更容易出现UU阳性（P = 0.04）。关于UU亚型，两组间解脲脲原体（Uuu）和微小脲原体（Uup;包括Uup 1、Uup 3、Uup 6和Uup 14）的患病率无差异。在两个不育组的男性中均未发现MH、MG和CT的患病率之间存在关联。根据粗模型，原发性不育男性中较低的精子浓度与STI病原体阳性相关（P = 0.04）。粗模型和校正模型显示精液量（P = 0.03）和精液白细胞计数（P = 0.02）与继发性不育独立相关。这些发现提示在精道感染的常规诊断中对不育类型进行分类的重要性。
This study aims to compare the prevalence of sexually transmitted infections (STIs) with semen quality in men from couples with primary and secondary infertility. Semen samples were collected from 133 men who requested fertility evaluation. Seminal tract infection with Ureaplasma spp. (UU), Mycoplasma hominis (MH), Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and herpes simplex virus-2 (HSV-2) was assessed by PCR-based diagnostic assays. Among all patients, the prevalence of STIs was higher in men from couples with primary infertility than that in men from couples with secondary infertility (39.7% vs 21.7%, P = 0.03). The prevalence of UU was 28.8% and 13.3% in men from couples with primary and secondary infertility, respectively. Men from couples with primary infertility were more likely to be positive for UU than men from couples with secondary infertility (P = 0.04). Regarding the UU subtype, the prevalence of Ureaplasma urealyticum (Uuu) and Ureaplasma parvum (Uup; including Uup1, Uup3, Uup6, and Uup14) did not differ between the two groups. No associations between the prevalence rates of MH, MG, and CT were found in men from either infertility group. A lower sperm concentration was associated with STI pathogen positivity in men with primary infertility according to the crude model (P = 0.04). The crude and adjusted models showed that semen volume (both P = 0.03) and semen leukocyte count (both P = 0.02) were independently associated with secondary infertility. These findings suggest the importance of classifying the type of infertility during routine diagnosis of seminal tract infections.
登录
查看更多内容
DOI：
10.1016/j.jmii.2016.09.004
发表时间：
2018-12-01
影响因子：
7.4
作者：
Zhou, Yun Heng;Ma, Hong Xia;Liu, Yang
通讯作者：
Liu, Yang
影响因子：
2.4
作者：
Moretti, E.;Federico, M. G.;Collodel, G.
通讯作者：
Collodel, G.
影响因子：
3.1
作者：
Majumdar, Gaurav;Majumdar, Abha
通讯作者：
Majumdar, Abha
影响因子：
6.7
作者：
Boeri, Luca;Pederzoli, Filippo;Salonia, Andrea
通讯作者：
Salonia, Andrea
影响因子：
3.7
作者：
Sami N;Ali TS;Wasim S;Saleem S
通讯作者：
Saleem S