Medial thalamus in the territory of oculomotor basal ganglia represents stable object value.
Medial thalamus in the territory of oculomotor basal ganglia represents stable object value.
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DOI：
10.1111/ejn.14202
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Hikosaka O
中科院分区：
文献类型：
--
作者：
Yasuda M;Hikosaka O
许多视觉对象都带有我们悠久的历史所创造的价值。这种稳定的物体价值吸引着人们的目光。我们发现基底神经节从网状黑质尾侧-背侧-外侧（cdlSNr）到上丘（SC）的输出通路携带稳健的稳定的价值信号来执行有价值物体的自动选择。这里的一个重要问题是，基底节区的稳定值信号是否会影响其他内部处理，如知觉、注意、情绪或觉醒，而不是运动执行。关键的脑回路是基底神经节的另一条输出通路：从信噪比到颞叶和额叶通过丘脑的通路。为了检验这一通路中是否存在稳定值信号，我们在大范围内对丘脑进行了研究。我们发现丘脑内侧许多神经元呈现稳定值。组织学检查显示，这些神经元的记录部位包括腹前核、大细胞部（VAmc），这是黑丘脑投射的主要目标。与SNr gabaric投影一致，值信号在内侧丘脑的潜伏期比cdlSNr晚，值编码在内侧丘脑的信号与cdlSNr相反。与cdlSNr神经元的情况一样，内侧丘脑神经元对频繁更新的值（灵活值）不敏感。这些结果表明，从cdlSNr到内侧丘脑的通路通过向宽皮质区域传播稳定的价值信号来影响认知加工的各个方面。
Many visual objects are attached with values which were created by our long rewarding history. Such stable object values attract gaze. We previously found that the output pathway of basal ganglia from caudal‐dorsal‐lateral portion of substantia nigra pars reticulata (cdlSNr) to superior colliculus (SC) carries robust stable value signal to execute the automatic choice of valuable objects. An important question here is whether stable value signal in basal ganglia can influence on other inner processing such as perception, attention, emotion, or arousal than motor execution. The key brain circuit is another output path of basal ganglia: the pathway from SNr to temporal and frontal lobes through thalamus. To examine the existence of stable value signal in this pathway, we explored thalamus in a wide range. We found that many neurons in the medial thalamus represented stable value. Histological examination showed that the recorded sites of those neurons included ventral anterior nucleus, pars magnocellularis (VAmc) which is the main target of nigrothalamic projection. Consistent with the SNr GABArgic projection, the latency of value signal in the medial thalamus was later than cdlSNr, and the sign of value coding in the medial thalamus was opposite to cdlSNr. As is the case with cdlSNr neurons, the medial thalamus neurons showed no sensitivity to frequently updated value (flexible value). These results suggest that the pathway from cdlSNr to the medial thalamus influences on various aspects of cognitive processing by propagating stable value signal to the wide cortical area.
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影响因子：
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作者：
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DOI：
10.1073/pnas.1104047108
发表时间：
2011-06-21
影响因子：
11.1
作者：
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