A Longitudinal Study of the Epidemiology of Seasonal Coronaviruses in an African Birth Cohort.
A Longitudinal Study of the Epidemiology of Seasonal Coronaviruses in an African Birth Cohort.
复制标题
DOI：
10.1093/jpids/piaa168
复制
发表时间：
2021-05-28
影响因子：
3.2
通讯作者：
Zar HJ
中科院分区：
文献类型：
--
作者：
Nicol MP;MacGinty R;Workman L;Stadler JAM;Myer L;Allen V;Ah Tow Edries L;Zar HJ
一项针对非洲婴儿的纵向研究表明，地方性冠状病毒感染很常见，并且与下呼吸道感染 (LRTI) 的相关性较弱，特别是冠状病毒-OC43，它也与住院的 LRTI 相关。由于非流行性季节性人类冠状病毒 (sHCoV) 通常感染儿童，因此更好地了解这些感染的流行病学可能有助于了解严重急性呼吸综合征 (SARS)-CoV-2 的背景。我们调查了出生后第一年 sHCoV 感染的流行病学，包括危险因素以及与下呼吸道感染 (LRTI) 的关联。我们对 2012 年至 2015 年南非开普敦附近的出生队列中的婴儿进行了一项巢式病例对照研究。实施了 LRTI 监测，并在婴儿期每两周收集一次鼻咽拭子。定量PCR检测到呼吸道病原体，包括冠状病毒-229E、-NL63、-OC43和-HKU1。对 LRTI 时和 90 天前的婴儿以及同期队列中年龄匹配的对照婴儿的拭子进行了测试。 总共纳入了 885 名婴儿，其中发生了 464 起 LRTI 事件。在 4751 个 sHCoV 样本检测中，9% 呈阳性，其中 HCoV-NL63 最为常见。季节性 HCoV 检测与 LRTI 相关；这种关联对于冠状病毒-OC43 最为强烈，在所有与 sHCoV 相关的住院治疗中也发现了这种关联。冬季出生与 sHCoV-LRTI 有关，但检测结果没有明显的季节性差异。肺炎链球菌的联合检测与 sHCoV-LRTI 呈弱相关（比值比：1.8；95% 置信区间：0.9-3.6）；其他呼吸道病毒或细菌的检测与 sHCoV 状态无关。 季节性 HCoV 感染很常见，并且与 LRTI 有关，特别是 sHCoV-OC43，它与 SARS 冠状病毒群关系最密切。冠状病毒与细菌在 LRTI 发病机制中的相互作用需要进一步研究。
A longitudinal study of African infants showed that endemic coronavirus infections were common and weakly associated with lower respiratory tract infection (LRTI), particularly coronavirus-OC43, which was also associated with hospitalized LRTIs. Since non-epidemic, seasonal human coronaviruses (sHCoV) commonly infect children, an improved understanding of the epidemiology of these infections may offer insights into the context of severe acute respiratory syndrome (SARS)-CoV-2. We investigated the epidemiology of sHCoV infection during the first year of life, including risk factors and association with lower respiratory tract infection (LRTI). We conducted a nested case-control study of infants enrolled in a birth cohort near Cape Town, South Africa, from 2012 to 2015. LRTI surveillance was implemented, and nasopharyngeal swabs were collected fortnightly over infancy. Quantitative PCR detected respiratory pathogens, including coronaviruses-229E, -NL63, -OC43, and -HKU1. Swabs were tested from infants at the time of LRTI and from the 90 days prior as well as from age-matched control infants from the cohort over the equivalent period. In total, 885 infants were included, among whom 464 LRTI events occurred. Of the 4751 samples tested for sHCoV, 9% tested positive, with HCoV-NL63 the most common. Seasonal HCoV detection was associated with LRTI; this association was strongest for coronavirus-OC43, which was also found in all sHCoV-associated hospitalizations. Birth in winter was associated with sHCoV-LRTI, but there were no clear seasonal differences in detection. Co-detection of Streptococcus pneumoniae was weakly associated with sHCoV-LRTI (odds ratio: 1.8; 95% confidence interval: 0.9-3.6); detection of other respiratory viruses or bacteria was not associated with sHCoV status. Seasonal HCoV infections were common and associated with LRTI, particularly sHCoV-OC43, which is most closely related to the SARS group of coronaviruses. Interactions of coronaviruses with bacteria in the pathogenesis of LRTI require further study.
登录
查看更多内容
DOI：
10.1016/j.tvjl.2010.03.001
发表时间：
2011-05
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
Atanasova K;Van Gucht S;Barbé F;Duchateau L;Van Reeth K
通讯作者：
Van Reeth K
DOI：
10.1016/s2213-2600(16)00096-5
发表时间：
2016-06
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Zar HJ;Barnett W;Stadler A;Gardner-Lubbe S;Myer L;Nicol MP
通讯作者：
Nicol MP
调查非洲疾病的早期决定因素：Drakenstein儿童健康研究。
影响因子：
10
作者：
Zar HJ;Barnett W;Myer L;Stein DJ;Nicol MP
通讯作者：
Nicol MP
影响因子：
--
作者：
Corman VM;Muth D;Niemeyer D;Drosten C
通讯作者：
Drosten C
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John