The insect microbiome modulates vector competence for arboviruses.

The insect microbiome modulates vector competence for arboviruses.
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DOI:
10.3390/v6114294
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发表时间:
2014-11-11
期刊:
Viruses
影响因子:
--
通讯作者:
Dimopoulos G
Dimopoulos G
中科院分区:
其他
文献类型:
--
作者:
Jupatanakul N;Sim S;Dimopoulos G

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由节肢动物传播的病毒(虫媒病毒)引起的疾病,如登革热、西尼罗河病毒和基孔肯雅热,构成了主要的全球卫生负担,并且在发病率和地理范围上都在增加。昆虫媒介的天然微生物群影响宿主生物学的各个方面,如营养、繁殖、代谢和免疫,最近的研究强调了昆虫相关细菌降低虫媒病毒和其他病原体媒介能力的能力。这种减少可以通过免疫反应激活、资源竞争或抗病毒分子的产生等机制发生。研究昆虫媒介及其微生物群之间的相互作用是制定虫媒病毒传播控制替代策略的重要一步。
Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and Chikungunya, constitute a major global health burden and are increasing in incidence and geographic range. The natural microbiota of insect vectors influences various aspects of host biology, such as nutrition, reproduction, metabolism, and immunity, and recent studies have highlighted the ability of insect-associated bacteria to reduce vector competence for arboviruses and other pathogens. This reduction can occur through mechanisms, such as immune response activation, resource competition, or the production of anti-viral molecules. Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control.
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