Brucellosis in pregnant women from Pakistan: an observational study.
Brucellosis in pregnant women from Pakistan: an observational study.
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DOI：
10.1186/s12879-016-1799-1
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发表时间：
2016-09-02
影响因子：
3.7
通讯作者：
Ali Q
中科院分区：
文献类型：
--
作者：
Ali S;Akhter S;Neubauer H;Scherag A;Kesselmeier M;Melzer F;Khan I;El-Adawy H;Azam A;Qadeer S;Ali Q
布鲁氏菌偶尔会引起自然流产。布鲁氏菌通常可通过摄入生奶或奶制品传播。本研究的目的是确定来自巴基斯坦拉瓦尔平迪的孕妇中布鲁氏菌病的血清流行率并确定潜在的危险因素。我们于2013年3月至6月在巴基斯坦拉瓦尔平迪贝娜齐尔·布托医院的妇科户外患者部门进行了一项横断面研究。在采血日通过个体访谈收集与潜在风险因素和临床病史相关的数据。采集的429份血清样本通过虎红平板凝集试验进行布鲁氏菌抗体检测的初步筛选。我们采用标准的描述性统计和逻辑回归分析。发现25份（5.8%; 95%置信区间（CI）：3.8%-8.5%）血清样品为血清阳性。在各种血清阳性病例中记录了布鲁氏菌病相关的临床症状。单变量分析显示，动物接触、食用生奶、流产史和宫内胎儿死亡与布鲁氏菌病血清阳性相关（所有p <0.05）。在多元逻辑回归模型中，只有与动物接触仍然是血清阳性的独立和稳健的风险因素（比值比5.21; 95% CI：1.88 - 13.75; p = 0.001）。在巴基斯坦，布鲁氏菌病对孕妇及其未出生的孩子构成严重威胁。有布鲁氏菌病相关症状或既往流产史、流产史、宫内胎儿死亡史和其他布鲁氏菌病相关表现的孕妇应进行布鲁氏菌病筛查--特别是暴露于动物的孕妇，因为风险增加--并应根据最新技术水平给予药物治疗。
Brucella species occasionally cause spontaneous human abortion. Brucella can be transmitted commonly through the ingestion of raw milk or milk products. The objective of this study was to determine the sero-prevalence of and to identify potential risk factors for brucellosis in pregnant women from Rawalpindi, Pakistan. We conducted a cross-sectional study at the Gynecology Outdoor Patient department of the Benazir Bhutto Hospital, Rawalpindi, Pakistan from March to June 2013. Data related to potential risk factors and clinical history was collected by individual interviews on the blood sampling day. The 429 serum samples collected were initially screened by Rose Bengal Plate Agglutination test for the detection of Brucella antibodies. We applied standard descriptive statistics and logistic regression analyses. Twenty five (5.8 %; 95 % confidence interval (CI): 3.8 % -8.5 %) serum samples were found to be seropositive. Brucellosis-related clinical symptoms were recorded in various seropositive cases. Animal contact, raw milk consumption, having an abortion history and the experience of an intrauterine fetal death were associated with seropositivity for brucellosis in univariate analyses (all p <0.05). In multiple logistic regression models only the contact with animals remained as independent and robust risk factor (odds ratio 5.21; 95 % CI: 1.88-13.75; p = 0.001) for seropositivity. Brucellosis is a serious threat for pregnant women and their unborn children in Pakistan. Pregnant women having brucellosis-related symptoms or previous history of abortions, miscarriages, intrauterine fetal death and other brucellosis-related manifestations should be screened for brucellosis – especially those exposed to animals given the increased risk – and medication should be administered according to state of the art.
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影响因子：
2.6
作者：
Kutlu, Murat;Ergonul, Onder;Kazak, Esra
通讯作者：
Kazak, Esra
影响因子：
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Cacace, Maria L.;Claros, Erica A.;Lucero, Nidia E.
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影响因子：
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影响因子：
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作者：
Ali, Shahzad;Ali, Qurban;Jamal, Syed M.
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