Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis.
Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis.
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DOI：
10.1186/s12903-020-01258-5
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发表时间：
2020-10-15
期刊：
影响因子：
2.9
通讯作者：
Palazzo G
中科院分区：
文献类型：
--
作者：
Isola G;Polizzi A;Patini R;Ferlito S;Alibrandi A;Palazzo G
本研究的目的是评估健康对照（HC）和牙周炎（PT）患者血清和唾液免疫球蛋白（Ig）聚集菌放线菌（A.放线菌）特异性抗体之间的关系。此外，目的是确定PT是否影响血清放线菌属特异性抗体，血清或唾液中针对放线菌属IgG的抗体是否由血清高敏c反应蛋白（hs-CRP）介导。本研究共纳入53例牙周炎患者和48例HC患者。定期对患者进行检查，并通过临床、唾液和血液样本分析来确定其特征。a .使用市售试剂盒评估放线菌的IgA和IgG抗体以及hs-CRP。采用Spearman相关试验和jonckheer - terpstra试验评估血清放线菌属IgG抗体与临床牙周参数的相关性。为了评估血清和唾液放线菌IgG水平对可能的混杂因素的依赖性，进行了单变量和多变量线性回归分析。与HC相比，PT患者血清IgA水平显著升高，PT为1.89 (1.2-2.2)EU vs HC为1.37 (0.9-1.8)EU (p = 0.022)；唾液：PT， 1.67 (1.4-2.1) EU vs HC, 1.42 (0.9-1.6) EU (p = 0.019)]和放线菌comitans IgG水平[血清：PT， 2.96 (2.1-3.7) EU vs HC, 2.18 (1.8-2.1) EU (p < 0.001)；唾液,PT, 2.19(1.8 - -2.5)欧盟与HC, 1.84(1.4 - 2)欧盟(p = 0.028)。在PT患者中，血清放线菌IgG与PT和牙齿脱落的比例程度相关（p趋势值< 0.001）。单因素回归分析显示，PT （p = 0.013）和高hs-CRP （p < 0.001）对血清和唾液放线菌IgG水平有显著的负向影响。多因素回归分析显示，PT （p = 0.033）、hs-CRP （p = 0.014）和BMI （p = 0.017）是血清放线菌线虫IgG的显著负向预测因子，hs-CRP （p < 0.001）和BMI （p = 0.025）是唾液放线菌线虫IgG的显著负向预测因子。与HC患者相比，PT患者血清和唾液a .放线菌IgA和IgG明显升高。当患者出现PT的进展程度时，血清放线菌IgG水平显著升高。此外，PT和hs-CRP是唾液和血清放线菌IgG水平升高的显著阴性预测因子。该研究已在clinicaltrials.gov （NCT04417322）上回顾性注册。
The aim of this study was to assess the association between serum and salivary Immunoglobulin (Ig) Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) specific antibodies in healthy controls (HC) and periodontitis (PT) patients. Furthermore, the objectives were to determine whether PT influenced serum A. actinomycetemcomitans specific antibodies and whether serum or salivary antibodies against A. actinomycetemcomitans IgG were mediated by serum high-sensitivity c-reactive protein (hs-CRP). Fifty-three patients with periodontitis and 48 HC were enrolled in the present study. Patients were regularly examined and characterized by clinical, salivary and blood samples analyses. A. actinomycetemcomitans IgA and IgG antibodies and hs-CRP were evaluated using a commercially available kit. The Spearman Correlation Test and Jonckheere-Terpstra Test were applied in order to assess the interdependence between serum A. actinomycetemcomitans IgG antibodies and clinical periodontal parameters. To evaluate the dependence of the serum and salivary A. actinomycetemcomitans IgG levels from possible confounders, univariate and multivariable linear regression analyses were performed. Compared to HC, patients with PT had significantly higher IgA [serum: PT, 1.89 (1.2–2.2) EU vs HC, 1.37 (0.9–1.8) EU (p = 0.022); saliva: PT, 1.67 (1.4–2.1) EU vs HC, 1.42 (0.9–1.6) EU (p = 0.019)] and A. actinomycetemcomitans IgG levels [serum: PT, 2.96 (2.1–3.7) EU vs HC, 2.18 (1.8–2.1) EU (p < 0.001); saliva, PT, 2.19 (1.8–2.5) EU vs HC, 1.84 (1.4–2) EU (p = 0.028)]. In PT patients, serum A. actinomycetemcomitans IgG were associated with a proportional extent of PT and tooth loss (P-trend value< 0.001). The univariate regression analysis demonstrated that PT (p = 0.013) and high hs-CRP (p < 0.001) had a significant negative effect on serum and salivary A. actinomycetemcomitans IgG levels. The multivariate regression analysis showed that PT (p = 0.033), hs-CRP (p = 0.014) and BMI (p = 0.017) were significant negative predictors of serum A. actinomycetemcomitans IgG while hs-CRP (p < 0.001) and BMI (P = 0.025) were significant negative predictors of salivary A. actinomycetemcomitans IgG. PT patients presented a significantly higher serum and salivary A. actinomycetemcomitans IgA and IgG compared to HC. There was a significant increase in serum A. actinomycetemcomitans IgG when patients presented a progressive extent of PT. Moreover, PT and hs-CRP were significant negative predictors of increased salivary and serum A. actinomycetemcomitans IgG levels. The study was retrospectively registered at clinicaltrials.gov (NCT04417322).
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