Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis.
Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis.
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DOI：
10.1007/s00403-013-1417-7
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发表时间：
2014-01
影响因子：
3
通讯作者：
Jagdeo J
中科院分区：
文献类型：
--
作者：
Babalola O;Mamalis A;Lev-Tov H;Jagdeo J
光学相干断层扫描（OCT）是一种非侵入性成像模式，正在改变皮肤科和其他医学领域的临床诊断。OCT提供表皮和真皮的横截面评估，并允许皮肤胶原蛋白的体内成像。上调的胶原蛋白含量是纤维化皮肤病的关键特征。这些疾病通常由从业者对疾病严重程度和对治疗的反应的主观评估来管理。本综述的目的是概述OCT的原理，并提供OCT在体内对皮肤胶原蛋白成像的能力的现有证据，以诊断和治疗以皮肤纤维化为特征的疾病。我们回顾了OCT研究，这些研究描述了正常皮肤和纤维化皮肤疾病（包括系统性硬化症和继发于烧伤、创伤和其他损伤的增生性瘢痕）中胶原蛋白含量的特征。我们还强调了OCT的几个局限性，并建议增强皮肤纤维化的OCT成像。我们的结论是，OCT成像有可能作为一个客观的，非侵入性的测量胶原蛋白的状态和疾病进展的研究试验和临床实践中使用。未来使用OCT成像作为纤维化的定量成像生物标志物将有助于识别纤维化，并促进临床检查，以纵向监测对治疗的反应，而不依赖于连续活检。使用OCT技术量化纤维化正处于形成阶段，我们预见到巨大的增长潜力，类似于过去30年发展的超声发展模式。
Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These diseases are often managed by the practitioner’s subjective assessment of disease severity and response to therapies. The purpose of this review is to provide an overview of the principles of OCT and present available evidence on the ability of OCT to image skin collagen in vivo for the diagnosis and management of diseases characterized by skin fibrosis. We review OCT studies that characterize the collagen content in normal skin and fibrotic skin diseases including systemic sclerosis and hypertrophic scars secondary to burn, trauma, and other injury. We also highlight several limitations of OCT and suggest enhancements to improve OCT imaging of skin fibrosis. We conclude that OCT imaging has the potential to serve as an objective, non-invasive measure of collagen’s status and disease progression for use in both research trials and clinical practice. The future use of OCT imagining as a quantitative imaging biomarker of fibrosis will help identify fibrosis and facilitate clinical examination in monitoring response to treatment longitudinally without relying on serial biopsies. The use of OCT technology for quantification of fibrosis is in the formative stages and we foresee tremendous growth potential, similar to the ultrasound development paradigm that evolved over the past 30 years.
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影响因子：
5.3
作者：
Han, Jae-Ho;Kang, Jin U.;Song, Chul Gyu
通讯作者：
Song, Chul Gyu
影响因子：
3.4
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影响因子：
3.4
作者：
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通讯作者：
Jemec, Gregor B. E.
影响因子：
3.5
作者：
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通讯作者：
Studer, Rebecca K.
影响因子：
3.5
作者：
Pan, Yingtian;Farkas, Daniel L.
通讯作者：
Farkas, Daniel L.