Computational design of drainage systems for vascularized scaffolds.
Computational design of drainage systems for vascularized scaffolds.
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DOI：
10.1016/j.biomaterials.2009.04.053
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发表时间：
2009-09
期刊：
影响因子：
14
通讯作者：
Tien, Joe
中科院分区：
文献类型：
--
作者：
Truslow, James G.;Price, Gavrielle M.;Tien, Joe
这项计算研究分析了如何设计多孔支架的引流系统，使支架可以血管化和灌注而不会导致血管腔塌陷。我们假设血管透壁压（管腔压和间质压之差）必须超过一个阈值以避免塌陷。模型的几何形状包括在各向同性支架，其中一个小的子集的通道被选择用于排水的开放通道的六边形阵列。流体流过血管和引流通道、流过血管壁和流过支架分别受纳维尔-斯托克斯方程、斯特林过滤定律和达西定律的支配。我们发现，每个引流通道只能在附近的血管中维持阈值跨壁压，作用半径取决于血管几何形状和血管壁和支架的水力特性。我们说明了如何将这些结果可以应用于微血管组织工程，并建议支架的设计与灌注和排水铭记。
This computational study analyzes how to design a drainage system for porous scaffolds so that the scaffolds can be vascularized and perfused without collapse of the vessel lumens. We postulate that vascular transmural pressure—the difference between lumenal and interstitial pressures—must exceed a threshold value to avoid collapse. Model geometries consisted of hexagonal arrays of open channels in an isotropic scaffold, in which a small subset of channels was selected for drainage. Fluid flow through the vessels and drainage channel, across the vascular wall, and through the scaffold were governed by Navier-Stokes equations, Starling’s Law of Filtration, and Darcy’s Law, respectively. We found that each drainage channel could maintain a threshold transmural pressure only in nearby vessels, with a radius-of-action dependent on vascular geometry and the hydraulic properties of the vascular wall and scaffold. We illustrate how these results can be applied to microvascular tissue engineering, and suggest that scaffolds be designed with both perfusion and drainage in mind.
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影响因子：
4.3
作者：
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