Calcineurin-modulated antimicrobial peptide expression is required for the development of Helicoverpa armigera

Calcineurin-modulated antimicrobial peptide expression is required for the development of Helicoverpa armigera
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棉铃虫发育需要钙调神经磷酸酶调节的抗菌肽表达

DOI:
10.3389/fphys.2019.01312
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发表时间:
2019-10
影响因子:
4
通讯作者:
Shiheng An
Shiheng An
中科院分区:
医学2区
文献类型:
--
作者:
Jizhen Wei;Linhong Li;Shuangyan Yao;Shuo Yang;Shuai Zhou;Xiaoguang Liu;Mengfang Du;Shiheng An

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棉铃虫是世界各地普遍存在的害虫,已被广泛用作农业害虫的模式生物。钙调神经磷酸酶 (CAN) 是一种重要的 Ca2+ 依赖性磷酸酶,参与多种生物途径。在这里,我们发现 CAN 抑制通过减少幼虫重量、延长发育时间和降低化蛹率来显着抑制棉铃虫幼虫发育。此外,CAN 还可作为免疫激活剂,通过与棉铃虫中的 relish 转录因子结合来调节抗菌肽(AMP;天蚕素 D、attacin 和 gloverin)的表达。本研究为利用农药增效剂或植物介导的RNA干扰技术控制棉铃虫提供了潜在的靶点。
Helicoverpa armigera is a universal pest around the world that has been extensively used as a model organism for agricultural pests. Calcineurin (CAN) is an important Ca2+-dependent phosphatase that is participated in various biological pathways. Here, we revealed that CAN inhibition significantly arrested H. armigera larval development by reducing larvae weight, prolonging development time and reducing pupate rates. Furthermore, CAN serves as an immune activator and regulates antimicrobial peptide (AMP; cecropin D, attacin, and gloverin) expression by binding with relish transcript factor in H. armigera. This study provides a potential target to control H. armigera by using synergistic agents for pesticides or plant-mediated RNA interference technology.
DOI: 10.1097/wnr.0b013e32833eaade
发表时间: 2010-10
期刊: NeuroReport
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