Topographic Organization of Correlation Along the Longitudinal and Transverse Axes in Rat Hippocampal CA3 Due to Excitatory Afferents.
Topographic Organization of Correlation Along the Longitudinal and Transverse Axes in Rat Hippocampal CA3 Due to Excitatory Afferents.
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DOI：
10.3389/fncom.2020.588881
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发表时间：
2020
影响因子：
3.2
通讯作者：
Berger TW
中科院分区：
文献类型：
--
作者：
Yu GJ;Bouteiller JC;Berger TW
海马 CA3 亚区传入神经的地形组织已得到充分研究，但它们在影响群体活动时空动态方面的作用尚不清楚。使用内嗅-齿状-CA3系统的大规模计算神经元网络模型，研究了穿孔路径、苔藓纤维和关联系统对网络尖峰模式的传播和转换的影响。构建了相关图来表征成对相关性的空间结构和时间演化，这些相关性是人口活动中发现的新兴模式的基础。关联系统的地形组织引起了沿CA3纵轴和横轴的空间关联结构的变化。由此产生的梯度可以为在海马体中观察到的已知功能组织提供基础。
The topographic organization of afferents to the hippocampal CA3 subfield are well-studied, but their role in influencing the spatiotemporal dynamics of population activity is not understood. Using a large-scale, computational neuronal network model of the entorhinal-dentate-CA3 system, the effects of the perforant path, mossy fibers, and associational system on the propagation and transformation of network spiking patterns were investigated. A correlation map was constructed to characterize the spatial structure and temporal evolution of pairwise correlations which underlie the emergent patterns found in the population activity. The topographic organization of the associational system gave rise to changes in the spatial correlation structure along the longitudinal and transverse axes of the CA3. The resulting gradients may provide a basis for the known functional organization observed in hippocampus.
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影响因子：
25
作者：
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通讯作者：
Buzsáki, G
影响因子：
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