Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans.
Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans.
复制标题
DOI：
10.1126/sciadv.adf5056
复制
发表时间：
2023-02-22
期刊：
影响因子：
13.6
通讯作者：
Ding, Xiaoyun
中科院分区：
文献类型：
--
作者：
Bhadra, Joyita;Sridhar, Nakul;Fajrial, Apresio Kefin;Hammond, Nia;Xue, Ding;Ding, Xiaoyun
有规律的体育锻炼已被证明可以延缓和减轻神经退行性疾病。然而，提供神经元保护和运动相关因素的最佳体育锻炼条件仍然知之甚少。在这里，我们通过表面声波（SAW）微流控技术在芯片上创建一个声学健身房，以精确控制模式生物游泳运动的持续时间和强度。我们发现，通过声流实现的精确剂量的游泳运动减少了两种不同的秀丽隐杆线虫神经退行性疾病模型（帕金森病模型和tau蛋白病模型）中的神经元损失。这些发现强调了最佳运动条件对有效保护神经元的重要性，这是老年人群健康老龄化的一个关键特征。这种SAW装置还为筛选可以增强或取代运动有益效果的化合物以及确定治疗神经退行性疾病的药物靶点铺平了道路。Acoustic Gym技术揭示了精确剂量的适度游泳运动可以减少C。优雅
Regular physical exercise has been shown to delay and alleviate neurodegenerative diseases. Yet, optimum physical exercise conditions that provide neuronal protection and exercise-related factors remain poorly understood. Here, we create an Acoustic Gym on a chip through the surface acoustic wave (SAW) microfluidic technology to precisely control the duration and intensity of swimming exercise of model organisms. We find that precisely dosed swimming exercise enabled by acoustic streaming decreases neuronal loss in two different neurodegenerative disease models of Caenorhabditis elegans, a Parkinson’s disease model and a tauopathy model. These findings highlight the importance of optimum exercise conditions for effective neuronal protection, a key characteristic of healthy aging in the elderly population. This SAW device also paves avenues for screening for compounds that can enhance or replace the beneficial effects of exercise and for identifying drug targets for treating neurodegenerative diseases. The Acoustic Gym technology reveals that precisely dosed moderate swimming exercise reduces neurodegeneration in C. elegans.
登录
查看更多内容
DOI：
10.1073/pnas.0400848101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Huang, C;Xiong, CJ;Kornfeld, K
通讯作者：
Kornfeld, K
影响因子：
64.8
作者：
Herndon, LA;Schmeissner, PJ;Driscoll, M
通讯作者：
Driscoll, M
影响因子：
4.6
作者：
Bai, Cheng;Zhou, Wen;Wang, Chaohui
通讯作者：
Wang, Chaohui
影响因子：
6.1
作者：
Hulme, S. Elizabeth;Shevkoplyas, Sergey S.;Whitesides, George M.
通讯作者：
Whitesides, George M.
影响因子：
4.7
作者：
Lakso, M;Vartiainen, S;Wong, G
通讯作者：
Wong, G