Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles.
Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles.
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DOI：
10.1111/ejn.13673
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Lei K;Liu Y;Smith AS;Lonstein JS;Wang Z
男性父母的照顾对青少年的发展和身心健康是至关重要的行为。然而，对男性父母行为的神经化学调控知之甚少，这主要是因为缺乏合适的动物模型。本研究以群居一夫一妻制的雄性草原田鼠(Microtus Ochrogaster)为研究对象，研究了配对结合经历对父亲行为和大脑伏核(NAcc)多巴胺(DA)信号的影响。我们比较了性幼稚的雄性和与雌性结成对持续两周的雄性。我们的数据显示，与性幼稚的雄性相比，配对结合的雄性表现出更强的父性行为，特别是在幼崽舔/梳理时，与NAcc中DA-1受体(D1R)蛋白的表达增加有关。特定部位的脑微透析显示，在两组雄性动物中，与幼鼠暴露相关的NAcc中DA释放显著但短暂地增加。此外，对NAcc中D1R的药物阻断减少了结对雄性幼崽的舔/梳理。总之，我们的数据表明，在雄性草原田鼠中，与雌性的配对联系经历通过NAcc D1R中介促进了雄性父母的行为。我们研究了雄性草原田鼠(M.ochrogaster)的父性行为。与性幼稚(SN)的雄性相比，与雌性配对2周(PB)的雄性表现出更强的舔幼崽/梳理幼崽的能力，并伴随着NAcc中多巴胺D1型受体(D1R)表达的增加。幼鼠暴露可引起NAcc内多巴胺释放的一过性增加，NAcc内注射3.0μg的D1R拮抗剂可减少幼鼠的舔舔/梳理。
Male parental care is a vital behavior for the development as well as the physical and mental well-being of the young. However, little is known about the neurochemical regulation of male parental behavior, mainly due to the lack of appropriate animal models. In the present study, we used the socially monogamous male prairie vole (Microtus ochrogaster) to investigate the effect of pair bonding experience on paternal behavior and dopamine (DA) signaling in the nucleus accumbens (NAcc) in the brain. We compared sexually naïve males with males that were pair-bonded with a female for two weeks. Our data showed that pair-bonded males displayed enhanced paternal behavior, particularly in pup licking/grooming, associated with increased DA type-1 receptor (D1R) protein expression in the NAcc, compared to sexually naïve males. Site-specific brain microdialysis revealed a significant, but transient, increase in DA release in the NAcc associated with pup exposure in both groups of the males. Further, pharmacological blockade of D1R in the NAcc decreased pup licking/grooming in the pair-bonded males. Together, our data demonstrate that pair bonding experience with a female facilitated male parental behavior via NAcc D1R mediation in male prairie voles. We studied paternal behavior in male prairie voles (M. ochrogaster). Compared to sexually naïve (SN) males, males that were paired-bonded with a female for 2-weeks (PB) showed enhanced pup licking/grooming associated with increased dopamine D1-type receptor (D1R) expression in the NAcc. Pup exposure induced a transient increase in dopamine release in the NAcc, and intra-NAcc administration of a D1R antagonist at 3.0μg diminished pup licking/grooming.
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