The art of cellular communication: tunneling nanotubes bridge the divide.
The art of cellular communication: tunneling nanotubes bridge the divide.
复制标题
DOI：
10.1007/s00418-008-0412-0
复制
发表时间：
2008-05
影响因子：
2.3
通讯作者：
Gerdes, Hans-Hermann
中科院分区：
文献类型：
--
作者：
Gurke, Steffen;Barroso, Joao F. V.;Gerdes, Hans-Hermann
细胞接收、处理和响应信息的能力对各种生物过程至关重要。这对于最简单的单细胞实体来说是正确的，因为它对于多细胞生物的高度特化的细胞来说也是如此。在后者中，大多数细胞不是作为独立的单位存在，而是组织成专门的组织。在这些功能组件中，细胞以不同的方式相互通信以协调生理过程。最近，一种新型的细胞间通讯被发现，基于细胞间膜状纳米管的重新形成。这些富含F-肌动蛋白的结构，被称为隧道纳米管（TNT），被证明可以介导连接细胞之间的膜连续性，并促进各种细胞成分的细胞间运输。随后在许多细胞类型中鉴定出TNT样结构，揭示了一些结构多样性。与此同时，出现了细胞之间货物的直接转移是一种常见的功能特性，这表明TNT样结构在选择性，长距离细胞间通讯中的一般作用。由于越来越多的记录薄和长的细胞突起在组织中涉及细胞间信号传导，这是有趣的推测，TNT样结构也存在于体内，并参与重要的生理过程。
The ability of cells to receive, process, and respond to information is essential for a variety of biological processes. This is true for the simplest single cell entity as it is for the highly specialized cells of multicellular organisms. In the latter, most cells do not exist as independent units, but are organized into specialized tissues. Within these functional assemblies, cells communicate with each other in different ways to coordinate physiological processes. Recently, a new type of cell-to-cell communication was discovered, based on de novo formation of membranous nanotubes between cells. These F-actin-rich structures, referred to as tunneling nanotubes (TNT), were shown to mediate membrane continuity between connected cells and facilitate the intercellular transport of various cellular components. The subsequent identification of TNT-like structures in numerous cell types revealed some structural diversity. At the same time it emerged that the direct transfer of cargo between cells is a common functional property, suggesting a general role of TNT-like structures in selective, long-range cell-to-cell communication. Due to the growing number of documented thin and long cell protrusions in tissue implicated in cell-to-cell signaling, it is intriguing to speculate that TNT-like structures also exist in vivo and participate in important physiological processes.
登录
查看更多内容
影响因子：
4
作者：
Freund, Daniel;Bauer, Nicola;Corbeil, Denis
通讯作者：
Corbeil, Denis
影响因子：
78.5
作者：
Bjerkvig, R;Tysnes, BB;Terzis, AJA
通讯作者：
Terzis, AJA
影响因子：
3.3
作者：
Favoreel, HW;Van Minnebruggen, G;Nauwynck, HJ
通讯作者：
Nauwynck, HJ
影响因子：
9.2
作者：
Jacinto, A;Wood, W;Martin, P
通讯作者：
Martin, P
影响因子：
64.5
作者：
Gibson, MC;Schubiger, G
通讯作者：
Schubiger, G