Short-term and long-term effects of repeated social defeat during adolescence or adulthood in female rats.
Short-term and long-term effects of repeated social defeat during adolescence or adulthood in female rats.
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DOI：
10.1016/j.neuroscience.2013.01.073
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发表时间：
2013-09-26
期刊：
影响因子：
3.3
通讯作者：
Bhatnagar S
中科院分区：
文献类型：
--
作者：
Ver Hoeve ES;Kelly G;Luz S;Ghanshani S;Bhatnagar S
越来越多的证据表明，青春期是一个敏感时期，在此期间，社会压力源可能会影响成人的行为和压力反应。然而，关于青春期社会压力对女性行为或压力反应的影响知之甚少。在这项研究中，我们将青春期或成年雌性大鼠连续 7 天暴露在失败的重复社会压力下。与成年雌性大鼠相比，多次失败导致青少年在失败期间表现出明显不同的行为。青春期雌性表现出更多的玩耍和回避行为，而成年雌性则对常驻雌性表现出更积极和攻击性的行为。使用波尔索尔特强迫游泳测试（FST）检查社交失败的短期影响表明，与成年人相比，青少年无论是否遭受社交失败，都表现出不动的时间增加和游泳的时间减少。与年龄相匹配的幼稚老鼠相比，遭受失败的青春期老鼠也表现出更强的攀爬能力。这些影响随着年龄的增长而消失。有趣的是，在成年雌性中没有观察到失败的影响，然而，当这些雌性在失败结束后 30 天的 FST 中重新评估时，我们观察到游泳的次数增加，而攀爬的次数却减少了。通过暴露于一种新颖的约束来评估压力反应性，我们发现青春期和成年期间的压力导致基础 ACTH 浓度降低，并且与压力和控制成人组相比，压力和控制青少年组在成年后的恢复均表现出延迟。 Fos 蛋白分析进一步表明，皮质/丘脑结构是调节青春期压力长期影响的潜在底物。因此，与成年期重复的社会压力相比，青春期重复的社会压力会产生不同的影响模式。
Accumulating evidence suggests that adolescence represents a sensitive period during which social stressors may serve to influence adult behavior and stress reactivity. However, relatively little is known about the impact of social stress in adolescence on behaviors or stress reactivity in females. In this study, we exposed adolescent or adult female rats to the repeated social stress of defeat for 7 consecutive days. Repeated defeat resulted in distinctly different behavioral repertoires during defeat in adolescent compared to adult female rats. Adolescent females exhibited more play and avoidant behaviors and adult females exhibited more active and aggressive behaviors toward the resident female. Examination of the short-term effects of social defeat using the Porsolt-forced swim test (FST) indicated that adolescents, regardless of their exposure to social defeat, showed increased time immobile and decreased time swimming compared to adults. Adolescent rats exposed to defeat also exhibited increased climbing compared to their age–matched naïve counterparts. These effects dissipated with age. Interestingly, no effects of defeat were observed in adult females, however, when these females were re-assessed in the FST 30 days after the end of defeat, we observed increased swimming at the expense of climbing. Using exposure to a novel restraint to assess stress reactivity, we found that stress during adolescence and adulthood led to lower basal ACTH concentrations and that both stressed and control adolescent groups exhibited a delay in recovery in adulthood compared to stressed and control adult groups. Fos protein analysis further suggested that cortical/thalamic structures serve as potential substrates that mediate these long-term impacts of stress during adolescence. Thus, repeated social stress during adolescence produces different patterns of effects as compared with repeated social stress during adulthood.
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影响因子：
1.4
作者：
FLANNELLY, KJ;FLANNELLY, L
通讯作者：
FLANNELLY, L
影响因子：
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作者：
Foilb, Allison R.;Lui, Patina;Romeo, Russell D.
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作者：
Grissom, Nicola;Kerr, Wesley;Bhatnagar, Seema
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Bhatnagar, Seema
影响因子：
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作者：
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McEwen, BS
影响因子：
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作者：
Radley, Jason J.;Arias, Carlos M.;Sawchenko, Paul E.
通讯作者：
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