Association of Maternal Caffeine Consumption During Pregnancy With Child Growth.
Association of Maternal Caffeine Consumption During Pregnancy With Child Growth.
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DOI：
10.1001/jamanetworkopen.2022.39609
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发表时间：
2022-10-03
影响因子：
13.8
通讯作者：
Grantz, Katherine L.
中科院分区：
文献类型：
--
作者：
Gleason, Jessica L.;Sundaram, Rajeshwari;Mitro, Susanna D.;Hinkle, Stefanie N.;Gilman, Stephen E.;Zhang, Cuilin;Newman, Roger B.;Hunt, Kelly J.;Skupski, Daniel W.;Grobman, William A.;Nageotte, Michael;Robinson, Morgan;Kannan, Kurunthachalam;Grantz, Katherine L.
母亲的咖啡因摄入量与儿童的生长有关吗？这种联系是否存在于低摄入量人群中？在这项队列研究中，在4至8岁时，怀孕期间测量咖啡因和副黄嘌呤含量低的妇女的孩子比怀孕期间不摄入咖啡因的妇女的孩子矮，在8岁的历史队列中身高差距越来越大。没有明确的体重或体重指数变化模式。虽然相对较小的观察差异的临床意义尚不清楚，但这些研究结果表明，母亲每天摄入少量咖啡因与其后代的身材矮小有关，并持续到童年。这项队列研究评估了怀孕期间咖啡因摄入量和副黄嘌呤指标与儿童生长的关系。怀孕期间摄入更多的咖啡因与出生体重减少有关，但与儿童生长的潜在联系尚不清楚。在一个咖啡因摄入量低的当代队列和一个咖啡因摄入量高的历史队列中，评估妊娠期咖啡因和副黄嘌呤测量与儿童生长的相关性。国家儿童健康和人类发育胎儿生长研究所（ECHO-FGS; 10个研究中心，2009-2013）的环境对儿童健康结局的影响队列是一个妊娠队列，其中1个儿童测量年龄为4至8岁（2017-2019年随访）。围产期合作项目（CPP）是一个妊娠队列（12个研究中心，1959-1965），儿童随访8年（1960-1974）。目前的二次分析于二零二一年及二零二二年进行。咖啡因及其主要代谢产物，副黄嘌呤的浓度，定量从血浆（ECHO-FGS）和血清（CPP）收集在妊娠早期。分析的临界点由ECHO-FGS中的四分位数和CPP中的五分位数定义。在ECHO-FGS中评价了4 - 8岁儿童体重指数、体重和身高的Child z评分，以及脂肪质量指数和百分比以及1次测量的肥胖风险。在CPP队列的二次分析中，评价了儿童z评分和8岁纵向肥胖风险。在ECHO-FGS中（咖啡因摄入量中位数<50 mg/d），788名儿童（平均[SD]年龄，6.8 [1.0]岁; 411名男孩[52.2%]）在第四个四分位数与第一个四分位数的血浆咖啡因浓度的妇女有较低的身高z评分（β = −0.21; 95%CI，−0.41至−0.02），但仅在第三四分位数中观察到体重z评分的差异（β = −0.27; 95%CI，−0.47至−0.07）。在CPP，从4岁开始，1622名儿童在咖啡因摄入量最高的五分之一组中，有805名男孩（49.7%）的女性身高z分数低于咖啡因摄入量最低组的同龄人，而且随着年龄的增长，差距不断扩大（4年时β = −0.16 [95%CI，−0.31至−0.01]; 8年时β = −0.37 [95%CI，−0.57至−0.16]）。第三个五分位数与第一个五分位数中的儿童在5至8岁时体重略有下降（β =-0.16至-0.22）。两个队列中副黄嘌呤浓度的结果一致。宫内暴露于增加水平的咖啡因和副黄嘌呤，即使是少量，与儿童早期身材矮小有关。身高和体重降低的临床意义尚不清楚;然而，即使咖啡因摄入量低于临床推荐的指南（每天少于200 mg），这种降低也是明显的。
Is maternal caffeine consumption associated with child growth, and are such associations present in low-consumption groups? In this cohort study, at ages 4 to 8 years, children of women with low measured caffeine and paraxanthine during pregnancy were shorter than the children of women who consumed no caffeine during pregnancy, with increasing gaps in height in a historical cohort through age 8 years. There were no clear patterns of weight or body mass index changes. Although the clinical implications are unclear for relatively small observed differences, these findings suggest that small amounts of daily maternal caffeine consumption are associated with shorter stature in their offspring that persist into childhood. This cohort study evaluates the association of caffeine consumption during pregnancy and paraxanthine measures with child growth. Greater caffeine consumption in pregnancy is associated with reduced birth size, but potential associations with childhood growth are unclear. To evaluate the associations of pregnancy caffeine and paraxanthine measures with child growth in a contemporary cohort with low caffeine consumption and a historical cohort with high caffeine consumption. The Environmental Influences on Child Health Outcomes cohort of the National Institute of Child Health and Human Development Fetal Growth Studies (ECHO-FGS; 10 sites, 2009-2013) was a pregnancy cohort with 1 child measurement between ages 4 and 8 years (follow-up in 2017-2019). The Collaborative Perinatal Project (CPP) was a pregnancy cohort (12 sites, 1959-1965) with child follow-up through 8 years (1960-1974). The current secondary analysis was conducted in 2021 and 2022. Concentrations of caffeine and its primary metabolite, paraxanthine, were quantified from plasma (ECHO-FGS) and serum (CPP) collected in the first trimester. Cut points for analyses were defined by quartiles in ECHO-FGS and quintiles in CPP. Child z scores for body mass index, weight, and height were evaluated, as well as fat mass index and percentage and obesity risk measured at 1 time between age 4 and 8 years in ECHO-FGS. In a secondary analysis of the CPP cohort, child z scores and obesity risk longitudinally through age 8 years were evaluated. In ECHO-FGS (median caffeine intake <50 mg/d), 788 children (mean [SD] age, 6.8 [1.0] years; 411 boys [52.2%]) of women in the fourth vs first quartile of plasma caffeine concentrations had lower height z scores (β = −0.21; 95% CI, −0.41 to −0.02), but differences in weight z scores were only observed in the third quartile (β = −0.27; 95% CI, −0.47 to −0.07). In CPP, beginning at age 4 years, 1622 children (805 boys [49.7%]) of women in the highest caffeine quintile group had lower height z scores than their peers from the lowest group, with the gap widening with each successive year of age (β = −0.16 [95% CI, −0.31 to −0.01] at 4 years; β = −0.37 [95% CI, −0.57 to −0.16] at 8 years). There were slight reductions in weight at ages 5 to 8 years for children in the third vs first caffeine quintile (β = −0.16 to −0.22). Results were consistent for paraxanthine concentrations in both cohorts. Intrauterine exposure to increasing levels of caffeine and paraxanthine, even in low amounts, was associated with shorter stature in early childhood. The clinical implication of reductions in height and weight is unclear; however, the reductions were apparent even with levels of caffeine consumption below clinically recommended guidelines of less than 200 mg per day.
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影响因子：
2.3
作者：
Hoyt AT;Browne M;Richardson S;Romitti P;Druschel C;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
5.4
作者：
MYRIANTHOPOULOS, NC;FRENCH, KS
通讯作者：
FRENCH, KS
影响因子：
7.7
作者：
Grewal, Jagteshwar;Grantz, Katherine L.;Louis, Germaine M. Buck
通讯作者：
Louis, Germaine M. Buck
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
3.6
作者：
Bosy-Westphal, Anja;Plachta-Danielzik, Sandra;Mueller, Manfred J.
通讯作者：
Mueller, Manfred J.