Morphogenesis-inspired two-dimensional electrowetting in droplet networks
Morphogenesis-inspired two-dimensional electrowetting in droplet networks
复制标题
液滴网络中受形态发生启发的二维电润湿
DOI：
10.1088/1748-3190/acc779
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发表时间：
2023
影响因子：
3.4
通讯作者：
Freeman, Eric
中科院分区：
文献类型：
--
作者：
El-Beyrouthy, Joyce;Makhoul-Mansour, Michelle;Gulle, Jesse;Freeman, Eric
活组织通过形态发生过程中仔细调节的细胞间相互作用动态地重塑其内部细胞结构。这些细胞重排事件，例如细胞分选和相互组织扩散，已经使用差异粘附假说进行了解释，该假说描述了通过细胞与邻近细胞的粘附相互作用来对细胞进行分选。在这篇手稿中，我们探索了一种近似细胞组织的仿生脂质稳定乳液内差异粘附的简化形式。人造细胞组织是由在脂膜网络中粘附在一起的水滴集合而产生的。由于组织的这种抽象不保留通过生物机制局部改变界面粘附的能力，因此我们采用电润湿法，通过脂质成分的空间变化产生偏移，以捕获对组织特性的简单形式的生物电控制。这是通过首先在液滴网络中进行电润湿实验，然后创建一个模型来描述粘附液滴集合中的电润湿，然后根据实验测量验证模型来实现的。这项工作演示了如何通过脂质成分调节液滴网络内的电压分布，然后使用二维电润湿事件来塑造粘附结构的定向收缩。该模型的预测用于探索网络中复杂电润湿事件的控制机制，包括定向收缩和新界面的形成。
Living tissues dynamically reshape their internal cellular structures through carefully regulated cell-to-cell interactions during morphogenesis. These cellular rearrangement events, such as cell sorting and mutual tissue spreading, have been explained using the differential adhesion hypothesis, which describes the sorting of cells through their adhesive interactions with their neighbors. In this manuscript we explore a simplified form of differential adhesion within a bioinspired lipid-stabilized emulsion approximating cellular tissues. The artificial cellular tissues are created as a collection of aqueous droplets adhered together in a network of lipid membranes. Since this abstraction of the tissue does not retain the ability to locally vary the adhesion of the interfaces through biological mechanisms, instead we employ electrowetting with offsets generated by spatial variations in lipid compositions to capture a simple form of bioelectric control over the tissue characteristics. This is accomplished by first conducting experiments on electrowetting in droplet networks, next creating a model for describing electrowetting in collections of adhered droplets, then validating the model against the experimental measurements. This work demonstrates how the distribution of voltage within a droplet network may be tuned through lipid composition then used to shape directional contraction of the adhered structure using two-dimensional electrowetting events. Predictions from this model were used to explore the governing mechanics for complex electrowetting events in networks, including directional contraction and the formation of new interfaces.
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影响因子：
4.6
作者：
Makhoul-Mansour MM;El-Beyrouthy JB;Mao L;Freeman EC
通讯作者：
Freeman EC
影响因子：
17.1
作者：
Cazimoglu I;Booth MJ;Bayley H
通讯作者：
Bayley H
影响因子：
--
作者：
Mitalipov, Shoukhrat;Wolf, Don
通讯作者：
Wolf, Don
影响因子：
15
作者：
Hwang, William L.;Holden, Matthew A.;Bayley, Hagan
通讯作者：
Bayley, Hagan
影响因子：
15
作者：
Holden, Matthew A.;Needham, David;Bayley, Hagan
通讯作者：
Bayley, Hagan