Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes.
Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes.
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DOI：
10.1111/j.1460-9568.2009.06644.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Youngentob SL
中科院分区：
文献类型：
--
作者：
Homma R;Cohen LB;Kosmidis EK;Youngentob SL
我们比较了浓度依赖性的大鼠识别气味的能力与钙信号的神经末梢的嗅觉受体神经元。虽然识别性能下降的浓度以上和以下的培训刺激，它仍然远远高于随机在所有测试的浓度（0.0006%和35%之间的饱和蒸汽）。相反，在相同的清醒动物的钙信号远小于其最大值的气味浓度小于1%的饱和蒸汽。此外，激活肾小球的地图显着改变气味浓度降低。因此，知觉稳定性存在于面对的幅度和地图的输入到嗅球的戏剧性的变化。最敏感的肾小球对五种气味剂中的每一种的响应的浓度依赖性的数据用Michaelis-Menten（Hill）方程拟合。拟合曲线外推到比最小观测信号低几个数量级的气味剂浓度，并表明在低气味剂浓度下的钙响应比在饱和气味剂浓度下的响应小1000倍以上。我们推测，只有少数尖峰在嗅觉感觉神经元可能是足够的正确的气味识别。
We compared the concentration dependence of the ability of rats to identify odorants with the calcium signals in the nerve terminals of the olfactory receptor neurons. Although identification performance decreased with concentrations both above and below the training stimuli it remained well above random at all concentrations tested (between 0.0006% and 35% of saturated vapor). In contrast, the calcium signals in the same awake animals were much smaller than their maximum values at odorant concentrations less than 1% of saturated vapor. In addition, maps of activated glomeruli changed dramatically as odorant concentration was reduced. Thus perceptual stability exists in the face of dramatic changes in both the amplitude and the maps of the input to the olfactory bulb. The data for the concentration dependence of the response of the most sensitive glomeruli for each of five odorants was fitted with a Michaelis-Menten (Hill) equation. The fitted curves were extrapolated to odorant concentrations several orders of magnitude lower the smallest observed signals and suggest that the calcium response at low odorant concentrations is more than 1000 times smaller than the response at saturating odorant concentrations. We speculate that only a few spikes in olfactory sensory neurons may be sufficient for correct odorant identification.
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影响因子：
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