The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses.
The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses.
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DOI：
10.1038/ajg.2010.48
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发表时间：
2010-04
影响因子：
9.8
通讯作者：
Hoogerwerf, Willemijntje A.
中科院分区：
文献类型：
--
作者：
Nojkov, Borko;Rubenstein, Joel H.;Chey, William D.;Hoogerwerf, Willemijntje A.
轮班工作与胃肠道症状有关，如腹痛、便秘和腹泻。这些症状与功能性肠病患者报告的症状重叠。由于轮班工作将导致内源性昼夜节律计时系统与外部24小时环境之间的失调，我们假设轮班工作的护士与白班护士相比，功能性肠道疾病的患病率更高。邀请从事患者护理的护士填写Rome III、肠易激综合征生活质量量表（IBS-QOL）和修改后的Sleep-50问卷。受访者被分为白班、夜班或轮班。确定肠易激综合征、功能性便秘、功能性腹泻和个体胃肠道症状的患病率。399名护士（白班214名，夜班110名，轮班75名）的数据可用。轮班护士的IBS患病率明显高于白班护士（48%比31%，P < 0.01）。对年龄、性别和睡眠质量进行校正的多变量logistic回归证明了这种关联的稳健性。各组间IBS-QOL评分相似。两组间功能性便秘和功能性腹泻的患病率相似。轮班护士的腹痛患病率明显高于白班（81% vs. 54%, P < 0.0001）和夜班（61%,P = 0.003）。轮班工作，特别是轮班工作，与肠易激综合征和腹痛的发生有关，而这与睡眠质量无关。昼夜节律紊乱可能在肠易激综合征和腹痛的发病机制中起作用。
Shift work has been associated with gastrointestinal symptoms such as abdominal pain, constipation, and diarrhea. These symptoms overlap with those reported by patients with functional bowel disorders. Because shift work will lead to misalignment between the endogenous circadian timing system and the external 24 h environment, we hypothesized that nurses participating in shift work will have a higher prevalence of functional bowel disorders when compared with nurses participating in day shifts. Nurses engaged in patient care were invited to complete Rome III, irritable bowel syndrome–quality of life measure (IBS-QOL) and modified Sleep-50 questionnaires. Respondents were classified as working day, night, or rotating shifts. The prevalence of IBS, functional constipation, functional diarrhea, and individual gastrointestinal symptoms was determined. Data were available for 399 nurses (214 day shift, 110 night shift, and 75 rotating shift workers). Rotating shift nurses had a significantly higher prevalence of IBS compared to day shift nurses (48% vs. 31%, P < 0.01). Multivariable logistic regression correcting for age, gender, and sleep quality proved this association robust. IBS-QOL scores among groups were similar. Prevalence of functional constipation and functional diarrhea was similar between groups. Rotating shift nurses had a significantly higher prevalence of abdominal pain compared to day shift (81% vs. 54%, P < 0.0001) and night shift workers (61%, P = 0.003). Participation in shift work, especially rotating shift work, is associated with the development of IBS and abdominal pain that is independent of sleep quality. Circadian rhythm disturbances may have a function in the pathogenesis of IBS and abdominal pain.
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影响因子：
7.6
作者：
Lu, WZ;Gwee, KA;Ho, KY
通讯作者：
Ho, KY
影响因子：
10.3
作者：
Schernhammer, ES;Laden, F;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
5.6
作者：
Rotem, AY;Sperber, AD;Tarasiuk, A
通讯作者：
Tarasiuk, A
DOI：
10.1152/ajpgi.00402.2009
发表时间：
2010-02-01
影响因子：
4.5
作者：
Hoogerwerf, Willemijntje A.;Shahinian, Vahakn B.;Cassone, Vincent M.
通讯作者：
Cassone, Vincent M.
影响因子：
3.5
作者：
Cremonini, F.;Camilleri, M.;Zinsmeister, A. R.;Herrick, L. M.;Beebe, T.;Talley, N. J.
通讯作者：
Talley, N. J.