Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers.

Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers.
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人类对脑膜炎球菌的免疫力。 iv。人类志愿者中A组和C组脑膜炎球菌多糖的免疫原性。

DOI:
10.1084/jem.129.6.1367
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发表时间:
1969-06-01
影响因子:
15.3
通讯作者:
ARTENSTEIN, MS
ARTENSTEIN, MS
中科院分区:
医学1区
文献类型:
--
作者:
GOTSCHLICH, EC;GOLDSCHNEIDER, I;ARTENSTEIN, MS

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高分子量A群和C群脑膜炎球菌多糖对小鼠和豚鼠无明显毒性。此外,这些多糖制剂含有可忽略量的生物活性内毒素。高分子量的A组和C组脑膜炎球菌多糖在6名志愿者中是良好的免疫原。产生属于免疫球蛋白类别IgG、IgM和伊加的抗体。这些抗体在补体存在下具有高度的脑膜炎球菌杀伤性。
High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin. The high molecular weight group A and group C meningococcal polysaccharides were excellent immunogens in six human volunteers. Antibodies belonging to the immunoglobulin classes IgG, IgM, and IgA were produced. These antibodies were highly meningococcocidal in the presence of complement.
DOI: 10.1084/jem.82.3.207
发表时间: 1945-09-01
期刊: The Journal of experimental medicine
影响因子: --
作者:
Kabat EA;Bezer AE
通讯作者: Bezer AE
DOI: 10.1084/jem.88.3.369
发表时间: 1948-01-01
影响因子: 15.3
作者:
HEIDELBERGER, M;MACLEOD, CM;DILAPI, MM
通讯作者: DILAPI, MM
DOI: 10.1084/jem.129.6.1307
发表时间: 1969-06-01
期刊: The Journal of experimental medicine
影响因子: --
作者:
Goldschneider I;Gotschlich EC;Artenstein MS
通讯作者: Artenstein MS
DOI: 10.1128/jb.83.3.470-474.1962
发表时间: 1962-01-01
影响因子: 3.2
作者:
CATLIN, BW;SCHLOER, GM
通讯作者: SCHLOER, GM
DOI: 10.1084/jem.113.5.921
发表时间: 1961-01-01
影响因子: 15.3
作者:
DUBOS, RJ;SCHAEDLER, RW
通讯作者: SCHAEDLER, RW