On the way towards greener transition-metal-catalyzed processes as quantified by E factors.
On the way towards greener transition-metal-catalyzed processes as quantified by E factors.
复制标题
DOI：
10.1002/anie.201302020
复制
发表时间：
2013-10-11
影响因子：
16.6
通讯作者：
Slack, Eric D.
中科院分区：
文献类型：
--
作者：
Lipshutz, Bruce H.;Isley, Nicholas A.;Fennewald, James C.;Slack, Eric D.
过渡金属催化的碳-碳和碳-杂原子键形成是学术和工业环境中最常用的反应类型之一。尽管这些对合成社区很重要，但这种交叉耦合对我们的环境和可持续性来说代价高昂。E因子是产生的废物的一种度量，而有机溶剂到目前为止是与利用这些反应的制药和精细化学公司相关的高价值的主要贡献者。其中进行交叉偶联的有机溶剂的替代物可以以胶束催化的形式发现，其中由新引入的设计者表面活性剂组成的纳米颗粒能够实现相同的交叉偶联，尽管是在水中，其中大多数在室温下发生。在不存在有机溶剂作为反应介质的情况下，有机废物以及因此E因子显著下降。
Transition-metal-catalyzed carbon–carbon and carbon–heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment, and sustainability. E Factors are one measure of waste created, and organic solvents, by far, are the main contributors to the high values associated, in particular, with the pharmaceutical and fine-chemical companies which utilize these reactions. An alternative to organic solvents in which cross-couplings are run can be found in the form of micellar catalysis, wherein nanoparticles composed of newly introduced designer surfactants enable the same cross-couplings, albeit in water, with most taking place at room temperature. In the absence of an organic solvent as the reaction medium, organic waste and hence, E Factors, drop dramatically.
登录
查看更多内容
影响因子：
3.6
作者：
Lipshutz, Bruce H.;Ghorai, Subir;Abela, Alexander R.;Moser, Ralph;Nishikata, Takashi;Duplais, Christophe;Krasovskiy, Arkady;Gaston, Ricky D.;Gadwood, Robert C.
通讯作者：
Gadwood, Robert C.
影响因子：
3.4
作者：
Jimenez-Gonzalez, Concepcion;Ollech, Caleb;Bhathela, Neil
通讯作者：
Bhathela, Neil
影响因子：
9.8
作者：
Constable, DJC;Curzons, AD;Cunningham, VL
通讯作者：
Cunningham, VL
影响因子：
9.8
作者：
Hudlicky, T;Frey, DA;Brammer, LE
通讯作者：
Brammer, LE
室温下在水中进行有机催化，并在烧瓶内回收催化剂。
影响因子：
5.2
作者：
Lipshutz BH;Ghorai S
通讯作者：
Ghorai S