A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia.
A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia.
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DOI：
10.1016/j.nicl.2012.08.003
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发表时间：
2012
影响因子：
4.2
通讯作者：
Warburton, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Geva, Sharon;Baron, Jean-Claude;Jones, P. Simon;Price, Cathy J.;Warburton, Elizabeth A.
试图将卒中后认知或运动症状映射到病变位置的研究在文献中已有150多年的历史。在过去的二十年中，已经开发了两种计算技术来识别与行为障碍相关的病变部位。基于体素的形态测定法（VBM）现在已被广泛用于许多不同的患者群体。最近，基于体素的病变症状映射（VLSM）是专门为了识别中风患者的病变与症状关系而开发的，并已广泛用于研究功能、语言、运动能力和注意力等。然而，到目前为止，还没有研究比较这两种技术的结果。在这项研究中，我们比较了VLSM和VBM在20例慢性卒中后失语症患者的队列。这两种技术的比较表明，重叠的区域，以前发现是相关的任务，这表明使用这两种技术，并寻找它们之间的重叠，可以增加所获得的结果的可靠性。然而，整体VBM和VLSM提供了只有部分一致的结果和两种技术之间的差异进行了讨论。VLSM和VBM均用于卒中的病变-症状映射。到目前为止，还没有研究比较这两种方法的结果。在这里，VLSM和VBM在一组中风后失语症患者中进行了比较。VLSM和VLBM只提供了部分一致的结果。
Studies attempting to map post-stroke cognitive or motor symptoms to lesion location have been available in the literature for over 150 years. In the last two decades, two computational techniques have been developed to identify the lesion sites associated with behavioural impairments. Voxel Based Morphometry (VBM) has now been used extensively for this purpose in many different patient populations. More recently, Voxel-based Lesion Symptom Mapping (VLSM) was developed specifically for the purpose of identifying lesion–symptom relationships in stroke patients, and has been used extensively to study, among others functions, language, motor abilities and attention. However, no studies have compared the results of these two techniques so far. In this study we compared VLSM and VBM in a cohort of 20 patients with chronic post-stroke aphasia. Comparison of the two techniques showed overlap in regions previously found to be relevant for the tasks used, suggesting that using both techniques and looking for overlaps between them can increase the reliability of the results obtained. However, overall VBM and VLSM provided only partially concordant results and the differences between the two techniques are discussed. ► VBM and VLSM are both used for lesion–symptom mapping in stroke. ► No studies have compared the results of these two methods so far. ► Here, VLSM and VBM were compared in a cohort of patients with post-stroke aphasia. ► VBM and VLSM provide only partially concordant results.
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作者：
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影响因子：
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DOI：
10.1017/s1355617706061078
发表时间：
2006-11-01
影响因子：
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作者：
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