Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography.
Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography.
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DOI：
10.1016/j.ajo.2020.05.006
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发表时间：
2020-10
影响因子：
4.2
通讯作者：
Pepple KL
中科院分区：
文献类型：
--
作者：
Chu Z;Weinstein JE;Wang RK;Pepple KL
对葡萄膜炎患者的脉络膜毛细血管 (CC) 血流缺陷 (FD) 进行定量分析。回顾性横断面研究使用 PLEX® Elite 9000 获得基于扫描源光学相干断层扫描的血管造影 (SS-OCTA) 黄斑体积扫描（3×3 mm 和 6×6 mm）：使用自动血流不足识别算法生成和分析 Enface CC 图像。每只眼睛确定了三个定量指标：FD 数量 (FDN)、平均 FD 大小 (MFDS) 和 FD 密度 (FDD)。比较葡萄膜炎和对照眼之间的定量指标。葡萄膜炎队列根据是否存在脉络膜受累进一步细分，并比较亚组和正常对照之间的定量指标。本研究纳入了 38 名对照者的 38 只眼睛和 73 名葡萄膜炎受试者的 73 只眼睛。与对照眼相比，患有葡萄膜炎的眼睛具有显着更大的 CC MFDS (3×3 mm，p<0.0001；6×6 mm，p<0.0001) 和更高的 FDD (p=0.0002；p=0.0076)。进一步的分析确定，这些差异是由于脉络膜疾病亚组造成的，与正常对照（752 μm2，p<0.0001；802 μm2，p<0.0001）和无脉络膜受累的葡萄膜炎患者（785 μm2，785 μm2， p<0.0001；821μm2，p<0.0001）。对照组和无脉络膜受累患者的定量指标之间没有发现显着差异。 CC 的自动定量可以识别病理性 FD，并提供描述葡萄膜炎患者此类病变的定量指标。后葡萄膜炎患者的 CC FD 明显大于其他形式葡萄膜炎患者。
To perform a quantitative analysis of choriocapillaris (CC) flow deficits (FDs) in patients with uveitis. Retrospective cross-sectional study Swept-source optical coherence tomography based angiography (SS-OCTA) macular volume scans (3×3 mm and 6×6 mm) were obtained using the PLEX® Elite 9000: En face CC images were generated and analyzed using an automated flow deficit identification algorithm. Three quantitative metrics were determined for each eye: FD number (FDN), mean FD size (MFDS), and FD density (FDD). Quantitative metrics were compared between uveitis and control eyes. The uveitis cohort was further subdivided by the presence or absence of choroidal involvement, and quantitative metrics were compared between subgroups and normal controls A total of 38 eyes from 38 controls and 73 eyes from 73 uveitis subjects were included in this study. Eyes with uveitis have significantly larger CC MFDS (3×3 mm, p<0.0001; 6×6 mm, p<0.0001) and higher FDD (p=0.0002; p=0.0076) when compared to control eyes. Additional analysis determined that these differences are due to the choroidal disease subgroup, which demonstrates significantly larger MFDS (3×3 =1108 μm2; 6×6 =1104 μm2) compared to both normal controls (752 μm2, p<0.0001; 802 μm2, p<0.0001) and uveitis patients without choroidal involvement (785 μm2, p<0.0001; 821 μm2, p<0.0001). No significant differences were found between the quantitative metrics of controls and patients without choroidal involvement. Automated quantification of CC can identify pathological FDs and provide quantitative metrics describing such lesions in patients with uveitis. Posterior uveitis patients have significantly larger CC FDs than patients with other forms of uveitis.
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影响因子：
4.2
作者：
Kim, Alice Y.;Rodger, Damien C.;Shahidzadeh, Anoush;Chu, Zhongdi;Koulisis, Nicole;Burkemper, Bruce;Jiang, Xuejuan;Pepple, Kathryn L.;Wang, Ruikang K.;Puliafito, Carmen A.;Rao, Narsing A.;Kashani, Amir H.
通讯作者：
Kashani, Amir H.
影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
DOI：
10.1097/iae.0000000000001391
发表时间：
2017-08-01
影响因子：
3.3
作者：
Cheung, Chui Ming Gemmy;Yanagi, Yasuo;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
4.2
作者：
Borrelli, Enrico;Shi, Yue;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.
影响因子：
4.4
作者：
Kim AY;Chu Z;Shahidzadeh A;Wang RK;Puliafito CA;Kashani AH
通讯作者：
Kashani AH