Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography.
Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography.
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DOI：
10.1016/j.ajo.2016.08.035
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发表时间：
2016-11
影响因子：
4.2
通讯作者：
Kashani, Amir H.
中科院分区：
文献类型：
--
作者：
Kim, Alice Y.;Rodger, Damien C.;Shahidzadeh, Anoush;Chu, Zhongdi;Koulisis, Nicole;Burkemper, Bruce;Jiang, Xuejuan;Pepple, Kathryn L.;Wang, Ruikang K.;Puliafito, Carmen A.;Rao, Narsing A.;Kashani, Amir H.
使用SD-OCTA定量葡萄膜炎的视网膜毛细血管密度和形态。横断面观察性研究从两个三级眼科中心招募健康和葡萄膜炎受试者。原型SD-OCTA装置（Cirrus，Carl Zeiss Meditec，Inc.，都柏林，CA）生成以中央凹为中心的3×3 mm 2 OCTA图像。根据用于图像处理的光学微血管造影（OMAG）算法类型（强度和/或相位）和视网膜分割类型（自动或手动），将受试者分为3组。采用半自动化方法计算骨骼密度（SD）、血管密度（VD）、分形维数（FD）和血管直径指数（FDD）。在视网膜浅层（SRL）、视网膜深层（DRL）和非分段视网膜层（NS-RL）中评估视网膜血管系统。广义估计方程模型用于分析OCTA测量与视网膜各层内疾病状态之间的关联。P值< 0.05被认为是显著的。使用组内相关系数（ICC）评估再现性和重复性。葡萄膜炎眼的视网膜旁毛细血管的SD、VD和FD在所有视网膜节段均低于健康眼。此外，葡萄膜炎性黄斑水肿受试者的DRL中SD和VD显著较低。任何毛细血管参数与葡萄膜炎的解剖学分类均无相关性。葡萄膜炎中睫状体旁毛细血管密度和形态的定量分析表明毛细血管密度和复杂性显著降低。SD-OCTA算法足够强大，可以检测这些变化，并可以为葡萄膜炎受试者提供一种新的疾病诊断指标。
To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Cross-sectional, observational study Healthy and uveitic subjects were recruited from two tertiary care eye centers. Prototype SD-OCTA devices (Cirrus, Carl Zeiss Meditec, Inc., Dublin, CA) were used to generate 3×3 mm2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity-and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI). Retinal vasculature was assessed in the superficial retinal layer (SRL), deep retinal layer (DRL), and non-segmented retinal layer (NS-RL). A generalized estimating equations model was used to analyze associations between the OCTA measures and disease status within each retinal layer. A P value < 0.05 was accepted as significant. Reproducibility and repeatability were assessed using the Intraclass Correlation Coefficient (ICC). The SD, VD, and FD of the parafoveal capillaries were lower in uveitic eyes compared to healthy eyes in all retinal segments. In addition, SD and VD were significantly lower in the DRL of subjects with uveitic macular edema. There was no correlation in any capillary parameters and anatomic classification of uveitis. Quantitative analysis of parafoveal capillary density and morphology in uveitis demonstrates significantly lower capillary density and complexity. SD-OCTA algorithms are robust enough to detect these changes and can provide a novel diagnostic index of disease for uveitis subjects.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
7.6
作者：
Reif R;Qin J;An L;Zhi Z;Dziennis S;Wang R
通讯作者：
Wang R
DOI：
10.3928/23258160-20140909-08
发表时间：
2014-09
期刊：
Ophthalmic surgery, lasers & imaging retina
影响因子：
--
作者：
Huang Y;Zhang Q;Thorell MR;An L;Durbin MK;Laron M;Sharma U;Gregori G;Rosenfeld PJ;Wang RK
通讯作者：
Wang RK
影响因子：
1
作者：
Matsunaga, Douglas R.;Yi, Jack J.;Kashani, Amir H.
通讯作者：
Kashani, Amir H.
DOI：
10.1097/iae.0000000000000811
发表时间：
2015-11-01
影响因子：
3.3
作者：
Kashani, Amir H.;Lee, Sun Young;Puliafito, Carmen A.
通讯作者：
Puliafito, Carmen A.