The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.
复制标题
DOI：
10.1146/annurev-biochem-051710-134100
复制
发表时间：
2012
影响因子：
16.6
通讯作者：
Shilatifard A
中科院分区：
文献类型：
--
作者：
Shilatifard A
酿酒酵母Set 1/COMPASS是十多年前发现的第一个组蛋白H3赖氨酸4（H3 K4）甲基化酶。从那时起，已经证明Set 1/COMPASS及其酶产物H3 K4甲基化在进化树中高度保守。虽然酵母中只有一个COMPASS，但人类细胞至少有六个COMPASS家族成员，每个成员都能甲基化具有非冗余功能的H3 K4。在酵母中，组蛋白H2 B通过Rad 6/Bre 1的单泛素化是适当的H3 K4和H3 K79三甲基化所必需的。这种组蛋白串扰及其机制也是从酵母到人类高度保守的。在这篇综述中，将讨论组蛋白H2 B单泛素化依赖和独立的组蛋白H3 K4甲基化作为转录活性，增强子签名和发育平衡基因的标记的过程。组蛋白H2 B单泛素化和H3 K4甲基化的失调导致包括癌症在内的人类疾病的发病机制。还将审查这方面的最新调查结果。
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4) methylase identified over ten years ago. Since then, it has been demonstrated that Set1/COMPASS and its enzymatic product, H3K4 methylation, is highly conserved across the evolutionary tree. Although there is only one COMPASS in yeast, human cells bear at least six COMPASS family members each capable of methylating H3K4 with non-redundant functions. In yeast, the monoubiquitination of histone H2B by Rad6/Bre1 is required for proper H3K4 and H3K79 trimethylations. This histone crosstalk and its machinery are also highly conserved from yeast to human. In this review, the process of histone H2B monoubiquitination-dependent and independent histone H3K4 methylation as a mark of active transcription, enhancer signatures, and developmentally poised genes will be discussed. The misregulation of histone H2B monoubiquitination and H3K4 methylation results in the pathogenesis of human diseases including cancer. Recent findings in this regard will also be examined.
登录
查看更多内容
影响因子：
64.5
作者：
CHUANG, PT;ALBERTSON, DG;MEYER, BJ
通讯作者：
MEYER, BJ
影响因子：
64.8
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
影响因子：
56.9
作者：
Chuang, PT;Lieb, JD;Meyer, BJ
通讯作者：
Meyer, BJ
影响因子：
11.8
作者：
Akkers, Robert C.;van Heeringen, Simon J.;Jacobi, Ulrike G.;Janssen-Megens, Eva M.;Francoijs, Kees-Jan;Stunnenberg, Hendrik G.;Veenstra, Gert Jan C.
通讯作者：
Veenstra, Gert Jan C.
影响因子：
56.9
作者：
Buszczak, Michael;Paterno, Shelley;Spradling, Allan C.
通讯作者：
Spradling, Allan C.