Mandibular bone loss in ewe induced by hypothalamic-pituitary disconnection.
Mandibular bone loss in ewe induced by hypothalamic-pituitary disconnection.
复制标题
下丘脑-垂体断开引起的母羊下颌骨丢失
DOI：
10.1111/clr.12259
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发表时间：
2013
影响因子：
4.3
通讯作者：
Pogoda P
中科院分区：
文献类型：
--
作者：
Oheim R;Beil FT;Krause M;Bindl R;Ignatius A;Pogoda P
目的据推测人口变化将导致牙槽骨受损的患者数量增加。大型动物模型在这方面特别受关注，因为它们适合开发和测试新的牙种植体。最近，我们证明手术下丘脑-垂体断开（HPD）会导致明显的低周转情况，导致绵羊皮质骨和小梁骨丢失。本研究旨在探讨HPD手术对牙槽骨的影响。方法将10只成年美利奴母羊随机分为两组：对照组和HPD组。 6 个月后，我们通过组织形态计量学和高分辨率外周定量计算机断层扫描 (HR-pQCT) 分析了所有下颌骨的皮质骨和小梁骨。结果与 Controlewes 相比，HPDewes 的皮质厚度显着减少了约 20%，皮质孔隙率显着增加了约 20%，骨量显着减少了约 30%。结论我们的结果强调了骨转换的中枢调节机制的重要性。然而，还需要进一步的研究来详细了解骨转换的这些核心调节元件，并判断 HPD 羊对牙科研究的价值。
PurposeIt is supposed that the demographic change will lead to an increase in patients with impaired alveolar bone conditions. Large animal models are of particular interest in this context as they are suitable for developing and testing new dental implants. Recently, we demonstrated that surgical hypothalamo–pituitary disconnection (HPD) causes a pronounced low‐turnover situation leading to cortical and trabecular bone loss in sheep. In this study, we aimed to investigate the influence of the HPD procedure on the alveolar bone.MethodsTen adult Merino ewes were randomly assigned to two groups:ControlandHPD. After 6 months, we analysed the cortical and trabecular bone of all mandibles by histomorphometry and high‐resolution peripheral quantitative computed tomography (HR‐pQCT).ResultsHPDewes showed a significant decrease in cortical thickness by ~20%, a significant increase in cortical porosity by ~20% and a significant decrease in bone volume by ~30% in comparison withControlewes.ConclusionOur results underline the importance of central regulatory mechanisms of bone turnover. However, further studies are needed to understand these central regulatory elements of bone turnover in detail and to judge the value of the HPD sheep for dental research.
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DOI：
--
发表时间：
2008
期刊：
Journal of dentistry research
影响因子：
--
作者：
G. Dvorak;R. Gruber;Christian D. Huber;J. Goldhahn;G. Zanoni;D. Salaberger;G. Watzek;R. Haas
通讯作者：
R. Haas
骨质疏松症：对上颌骨骨吸收的影响以及通过植入假体进行治疗的可能性——文献综述和临床考虑。
DOI：
--
发表时间：
2003
期刊：
The international journal of periodontics & restorative dentistry
影响因子：
--
作者：
F. Sanfilippo;A. Bianchi
通讯作者：
A. Bianchi
影响因子：
3.3
作者：
Sigrist, Ilonka M.;Gerhardt, Christian;Egermann, Marcus
通讯作者：
Egermann, Marcus
骨质疏松绵羊模型中下颌骨的皮质孔隙度。
影响因子：
4.3
作者：
G. Dvorak;K. Reich;S. Tangl;J. Goldhahn;R. Haas;R. Gruber
通讯作者：
R. Gruber
影响因子：
4
作者：
E. Veigel;R. Moore;M. Zarrinkalam;D. Schulze;S. Sauerbier;R. Schmelzeisen;P. Voss
通讯作者：
P. Voss