A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.
A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.
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DOI：
10.1371/journal.pone.0016503
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发表时间：
2011-01-26
期刊：
影响因子：
3.7
通讯作者：
Mertens PP
中科院分区：
文献类型：
--
作者：
Castillo-Olivares J;Calvo-Pinilla E;Casanova I;Bachanek-Bankowska K;Chiam R;Maan S;Nieto JM;Ortego J;Mertens PP
非洲马瘟（AHS）是一种马类动物的致命病毒性疾病，由库蠓叮咬病毒血症宿主后感染传播。减毒活疫苗的使用对于流行地区控制这种疾病至关重要。然而，在非流行国家使用这些药物存在安全问题。因此，过去二十年的研究工作集中在开发基于表达AHS病毒粒子的结构组分的重组杆状病毒或活病毒载体的替代疫苗。然而，与在高度生物安全设施中使用受感染马匹有关的道德和财政考虑因素，进展非常缓慢。因此，我们评估了AHSV感染实验小鼠模型用于疫苗和免疫学研究的潜力。我们首先在该模型中表征了AHSV感染，然后测试了基于表达AHS-4 VP 2的修饰的安卡拉牛痘（MVA-VP 2）的重组疫苗的保护效力。
African horse sickness (AHS) is a lethal viral disease of equids, which is transmitted by Culicoides midges that become infected after biting a viraemic host. The use of live attenuated vaccines has been vital for the control of this disease in endemic regions. However, there are safety concerns over their use in non-endemic countries. Research efforts over the last two decades have therefore focused on developing alternative vaccines based on recombinant baculovirus or live viral vectors expressing structural components of the AHS virion. However, ethical and financial considerations, relating to the use of infected horses in high biosecurity installations, have made progress very slow. We have therefore assessed the potential of an experimental mouse-model for AHSV infection for vaccine and immunology research. We initially characterised AHSV infection in this model, then tested the protective efficacy of a recombinant vaccine based on modified vaccinia Ankara expressing AHS-4 VP2 (MVA-VP2).
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