Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.
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DOI：
10.1016/j.neurobiolaging.2009.04.002
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发表时间：
2009-07
影响因子：
4.2
通讯作者：
Morris, John C.
中科院分区：
文献类型：
--
作者：
Price, Joseph L.;McKeel, Daniel W., Jr.;Buckles, Virginia D.;Roe, Catherine M.;Xiong, ChengJie;Grundman, Michael;Hansen, Lawrence A.;Petersen, Ronald C.;Parisi, Joseph E.;Dickson, Dennis W.;Smith, Charles D.;Davis, Daron G.;Schmitt, Frederick A.;Markesbery, William R.;Kaye, Jeffrey F.;Kurlan, Roger;Hulette, Christine;Kurland, Brenda F.;Higdon, Roger;Kukull, Walter;Morris, John C.
旨在确定尸检的老年非痴呆个体中组织学阿尔茨海默病 (AD) 的发生频率和可能的认知影响。对来自 7 个阿尔茨海默病中心 (ADC) 的 97 例病例的老年斑 (SP) 和神经原纤维缠结 (NFT) 进行了定量评估。 AD (npAD) 的神经病理学诊断也根据四套标准进行。调整后的线性混合模型测试了患有和不患有 npAD 的参与者在死亡前定量神经病理学测量和心理测试分数上的差异。对于特定区域有病理的病例，计算了 AD 病变与最后评估时的心理测量评分之间的 Spearman 排序相关性。华盛顿大学阿尔茨海默病研究中心。 97 名非痴呆参与者死亡时年龄为 60 岁或以上（平均 84 岁）。大约 40% 的非痴呆个体至少满足一定程度的 npAD 标准；当使用严格的标准时，大约 20% 的病例患有 npAD。 npAD 和非 npAD 病例之间的 Braak 神经原纤维阶段存在大量重叠。尽管非 npAD 组或 npAD 组在死亡前没有可测量的认知障碍，但非痴呆老年患者的认知功能似乎因 NFT 和 SP 的存在而下降。在没有痴呆的人中，与 AD 相关的神经病理过程似乎与微妙的认知功能障碍有关，并且可能代表该疾病的临床前阶段。到了 80-85 岁，许多非痴呆老年人患有严重的 AD 病理。
To determine the frequency and possible cognitive effect of histological Alzheimer’s disease (AD) in autopsied older nondemented individuals. Senile plaques (SPs) and neurofibrillary tangles (NFTs) were assessed quantitatively in 97 cases from 7 Alzheimer’s Disease Centers (ADCs). Neuropathological diagnoses of AD (npAD) were also made with four sets of criteria. Adjusted linear mixed models tested differences between participants with and without npAD on the quantitative neuropathology measures and psychometric test scores prior to death. Spearman rank-order correlations between AD lesions and psychometric scores at last assessment were calculated for cases with pathology in particular regions. Washington University Alzheimer’s Disease Research Center. Ninety-seven nondemented participants who were age 60 years or older at death (mean = 84 years). About 40% of nondemented individuals met at least some level of criteria for npAD; when strict criteria were used, about 20% of cases had npAD. Substantial overlap of Braak neurofibrillary stages occurred between npAD and no-npAD cases. Although there was no measurable cognitive impairment prior to death for either the no-npAD or npAD groups, cognitive function in nondemented aging appears to be degraded by the presence of NFTs and SPs. Neuropathological processes related to AD in persons without dementia appear to be associated with subtle cognitive dysfunction and may represent a preclinical stage of the illness. By age 80–85 years, many nondemented older adults have substantial AD pathology.
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影响因子：
4.2
作者：
den Dunnen, Wilfred F. A.;Brouwer, Wiebo H.;Holstege, Gert
通讯作者：
Holstege, Gert
影响因子：
--
作者：
Haroutunian, V;Perl, DP;Mohs, RC
通讯作者：
Mohs, RC
影响因子：
--
作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
9.9
作者：
Ertekin-Taner, N.;Younkin, L. H.;Graff-Radford, N. R.
通讯作者：
Graff-Radford, N. R.
DOI：
10.1097/01.jnen.0000229986.17548.27
发表时间：
2006-08-01
影响因子：
3.2
作者：
Alafuzoff, Irina;Pikkarainen, Maria;Kretzschmar, Hans
通讯作者：
Kretzschmar, Hans