Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis
Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis
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童年和青春期的创伤经历：评估精神病风险的前瞻性研究的荟萃分析
DOI：
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发表时间：
2020
影响因子：
6.4
通讯作者：
F. Margari
中科院分区：
文献类型：
--
作者：
A. Pastore;G. de Girolamo;S. Tafuri;Aldo Tomasicchio;F. Margari
创伤经历和精神病之间的关联的证据是不确定的时间顺序，临床结果和年龄和遗传责任的作用。本荟萃分析的目的是探讨精神病的发展和创伤暴露之间的时间关系，采用前瞻性研究，并检查调节因素对整体效应量的作用。通过检索Embase-Ovid、PsycINFO（EBSCO）、Pubmed、Scopus、Web of Science数据库确定了研究，最初共产生了9016篇论文，筛选过程后最终留下23篇。使用随机效应模型，三组荟萃分析估计了经历过成人虐待或同龄人欺凌或父母死亡的精神病经历或完全临床精神病的风险。被同伴欺负（OR = 2.28 [1.64，4.34]）、被成年人虐待（OR = 2.20 [1.72，2.81]）和父母死亡（OR = 1.24 [1.06，1.44]）均增加精神病的风险。主持人分析表明，欺凌的负面影响被检测到，特别是在那些有精神病遗传倾向和暴露于多种创伤类型的研究;男性患病率较高的研究显示，那些暴露于父母死亡的风险更大。在发展为完全临床精神病或精神病经历的风险之间没有发现显著的荟萃回归。由于缺乏相关研究，影响了创伤发生年龄的研究结果.在童年和/或青春期被同龄人欺负和经历其他逆境的累积效应，以及精神病的遗传易感性，似乎赋予了以后生活中发展精神病症状的最高风险。
Evidence of the association between traumatic experiences and psychosis are uncertain with respect to temporal order, clinical outcomes and the role of the age and genetic liability. The aim of the present meta-analysis was to explore the temporal relationship between the development of psychosis and traumatic exposure using prospective studies and to examine the role of moderation factors on overall effect sizes. Studies were identified by searching Embase-Ovid, PsycINFO (EBSCO), Pubmed, Scopus, Web of Science databases, and yielded an initial total of 9016 papers, leaving finally 23 after the screening process. Three sets of meta-analyses estimated the risk of developing psychotic experiences or full clinical psychosis by having experienced maltreatment by an adult or bullying by peers or parental death, using the random-effects model. Bullying by peers (OR = 2.28 [1.64, 4.34]), maltreatment by an adult (OR = 2.20 [1.72, 2.81]) and parental death (OR = 1.24 [1.06, 1.44]) all increased the risk of psychosis. Moderator analysis showed that negative effects of bullying were detected especially in those with genetic liability for psychosis and exposure to multiple trauma types; studies with higher prevalence of males showed a stronger risk for those exposed to parental death. No significant meta-regression was found between the risk of developing a full clinical psychosis or a psychotic experience. Lack of studies hampered the results about the age of trauma occurrence. The cumulative effect of being bullied from peers and experiencing other adversities during childhood and/or adolescence, together with genetic liability for psychosis, appears to confer the highest risk for developing psychotic symptoms later in life.
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影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
基因与环境的相互作用导致精神分裂症的易感性：芬兰收养家庭精神分裂症研究的结果。
DOI：
10.1176/ajp.154.3.355
发表时间：
1997
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Wahlberg,KE;Wynne,LC;Oja,H;Keskitalo,P;Pykalainen,L;Lahti,I;Moring,J;Naarala,M;Sorri,A;Seitamaa,M;Laksy,K;Kolassa,J;Tienari,P
通讯作者：
Tienari,P
女性的压力生活事件、遗传倾向和重度抑郁症的发作。
DOI：
10.1176/ajp.152.6.833
发表时间：
1995
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Kendler,KS;Kessler,RC;Walters,EE;MacLean,C;Neale,MC;Heath,AC;Eaves,LJ
通讯作者：
Eaves,LJ
DOI：
10.1176/appi.ajp.2010.10040567
发表时间：
2011-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Arseneault L;Cannon M;Fisher HL;Polanczyk G;Moffitt TE;Caspi A
通讯作者：
Caspi A