Measuring longitudinal change in the hippocampal formation from in vivo high-resolution T2-weighted MRI.
Measuring longitudinal change in the hippocampal formation from in vivo high-resolution T2-weighted MRI.
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DOI：
10.1016/j.neuroimage.2012.01.098
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发表时间：
2012-04-02
期刊：
影响因子：
5.7
通讯作者：
Yushkevich, Paul A.
中科院分区：
文献类型：
--
作者：
Das, Sandhitsu R.;Avants, Brian B.;Pluta, John;Wang, Hongzhi;Suh, Jung W.;Weiner, Michael W.;Mueller, Susanne G.;Yushkevich, Paul A.
关键词：
海马结构（HF）是一个非常感兴趣的大脑结构，因为它在学习和记忆中的中心作用，以及它对几种神经系统疾病的相关脆弱性。体内斜冠状位T2加权MRI具有高平面内分辨率（~0.5 mm×0.5 mm）、厚切片（~2.0 mm）和专门用于海马结构成像的视野（本文中表示为HF-MRI），已被作为一种有用的成像模式用于详细的海马形态测量。对来自HF-MRI的体积测量的横截面分析表明，该模式有望为神经系统疾病（如阿尔茨海默病）提供灵敏的基于成像的生物标志物。然而，这种方式的效用，使纵向变化的测量尚未得到证明。在本文中，使用无偏的变形为基础的形态测量（DBM）管道，我们检查HF-MRI的适用性估计纵向变化，通过比较萎缩率测量在整个海马从这种方式与更常见的各向同性（~1 mm 3）T1加权MRI测量在同一组的个人，在一个队列的健康对照组和认知障碍患者。虽然从HF-MRI获得的测量结果与从T1-MRI获得的测量结果基本一致，但HF-MRI在患者中产生的萎缩率略高于对照组的组效应。与对照组相比，检测患者海马萎缩率变化25%（统计功效β=0.8）所需的估计最小样本量为N=269。对于T1-MRI，等效样本量为N=325。使用数据集的重测扫描，我们表明，测量是免费的添加剂偏见。我们还证明，这些结果并不是DBM管道中某些方法选择的混淆，以解决HF-MRI纵向测量的挑战，使用HF周围的感兴趣区域（ROI）来全局对齐序列图像，然后通过逐层可变形配准来测量局部体积变化。此外，我们提出了一个初步的研究萎缩率测量海马子领域使用高频MRI。在几个子领域中检测到萎缩率的横截面差异。
The hippocampal formation (HF) is a brain structure of great interest because of its central role in learning and memory, and its associated vulnerability to several neurological disorders. In vivo oblique coronal T2-weighted MRI with high in-plane resolution (~0.5 mm×0.5 mm), thick slices (~2.0 mm), and a field of view tailored to imaging the hippocampal formation (denoted HF-MRI in this paper) has been advanced as a useful imaging modality for detailed hippocampal morphometry. Cross-sectional analysis of volume measurements derived from HF-MRI has shown the modality’s promise to yield sensitive imaging-based biomarker for neurological disorders such as Alzheimer’s disease. However, the utility of this modality for making measurements of longitudinal change has not yet been demonstrated. In this paper, using an unbiased deformation-based morphometry (DBM) pipeline, we examine the suitability of HF-MRI for estimating longitudinal change by comparing atrophy rates measured in the whole hippocampus from this modality with those measured from more common isotropic (~1 mm3) T1-weighted MRI in the same set of individuals, in a cohort of healthy controls and patients with cognitive impairment. While measurements obtained from HF-MRI were largely consistent with those obtained from T1-MRI, HF-MRI yielded slightly larger group effect of greater atrophy rates in patients than in controls. The estimated minimum sample size required for detecting a 25% change in patients’ atrophy rate in the hippocampus compared to the control group with a statistical power β=0.8 was N=269. For T1-MRI, the equivalent sample size was N=325. Using a dataset of test–retest scans, we show that the measurements were free of additive bias. We also demonstrate that these results were not a confound of certain methodological choices made in the DBM pipeline to address the challenges of making longitudinal measurements from HF-MRI, using a region of interest (ROI) around the HF to globally align serial images, followed by slice-by-slice deformable registration to measure local volume change. Additionally, we present a preliminary study of atrophy rate measurements within hippocampal subfields using HF-MRI. Cross-sectional differences in atrophy rates were detected in several subfields.
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