Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration.
Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration.
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DOI：
10.1186/1423-0127-16-108
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发表时间：
2009-11-25
影响因子：
11
通讯作者：
Sethuraman S
中科院分区：
文献类型：
--
作者：
Subramanian A;Krishnan UM;Sethuraman S
神经组织的修复和再生策略受到了极大的关注，因为它直接影响到患者的生活质量。在使用传统的自体神经移植和新开发的重建受损神经的治疗策略的同时，再生神经面临着许多科学挑战。神经再生的最新进展涉及到组织工程学原理的应用，这为神经治疗提供了新的视角。神经组织工程的成功主要基于通过开发一种类似于天然细胞外基质的合成支架来调节细胞行为和组织进展，并能够支持三维细胞培养。由于天然细胞外基质为神经细胞的黏附和增殖提供了理想的地形、电和化学线索，因此需要开发一种生物相容性、免疫惰性、传导性、可生物降解性和抗感染的生物材料来支持神经突起的生长。该综述概述了通过使用合适的生物材料和支架技术来构建能够使神经元黏附、增殖并最终形成神经的结构，从而实现有效的神经组织工程的基本原理。
Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve while using conventional autologous nerve grafts and from the newly developed therapeutic strategies for the reconstruction of damaged nerves. Recent advancements in nerve regeneration have involved the application of tissue engineering principles and this has evolved a new perspective to neural therapy. The success of neural tissue engineering is mainly based on the regulation of cell behavior and tissue progression through the development of a synthetic scaffold that is analogous to the natural extracellular matrix and can support three-dimensional cell cultures. As the natural extracellular matrix provides an ideal environment for topographical, electrical and chemical cues to the adhesion and proliferation of neural cells, there exists a need to develop a synthetic scaffold that would be biocompatible, immunologically inert, conducting, biodegradable, and infection-resistant biomaterial to support neurite outgrowth. This review outlines the rationale for effective neural tissue engineering through the use of suitable biomaterials and scaffolding techniques for fabrication of a construct that would allow the neurons to adhere, proliferate and eventually form nerves.
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影响因子：
14
作者：
Burdick, JA;Ward, M;Langer, R
通讯作者：
Langer, R
影响因子：
14
作者：
Cheng, MY;Deng, JU;Zhang, XF
通讯作者：
Zhang, XF
影响因子：
14
作者：
Crompton, K. E.;Goud, J. D.;Forsythe, J. S.
通讯作者：
Forsythe, J. S.
DOI：
10.1007/s10856-005-0637-6
发表时间：
2005-04-01
影响因子：
3.7
作者：
Bini, TB;Gao, SJ;Ramakrishna, S
通讯作者：
Ramakrishna, S
影响因子：
14
作者：
Chew, Sing Ylan;Mi, Ruifa;Leong, Kam W.
通讯作者：
Leong, Kam W.