Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.
Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.
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基于多模态连接的分割揭示了人类伏隔核的壳核二分法
DOI：
10.1002/hbm.23636
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发表时间：
2017-08
影响因子：
4.8
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Xia X;Fan L;Cheng C;Eickhoff SB;Chen J;Li H;Jiang T
伏隔核（NAc）的亚分化已经通过神经解剖学和组织化学进行了广泛的研究，得到了一个被广泛接受的反映可分离作用的壳/核二分结构，例如分别在奖励和厌恶中。然而，这些结构在人类体内的分割非常罕见，这可能会影响未来对NAc亚区结构和功能特征以及改变的研究。在这里，我们使用了三种互补的分割方案，基于束状图，任务无关的功能连接和任务相关的协同激活来研究NAc内的区域分化。我们发现，具有壳状和核状细分的2簇解决方案提供了对数据的最佳描述，并且与早期的解剖壳/核结构一致。基于这三种方案的最优解的共识聚类被用作后续连接分析的最终包。由此产生的连接模式呈现出半球间的对称性，在模式上的收敛和发散，最重要的是，两个次区域之间的模式明显不同。这种趋同的连接模式也证实了动物模型中的连接，支持了这两个子区域在某些情况下可能具有对抗作用的观点。最后，确定的包块应该有助于NAc的进一步神经影像学研究。
The subdifferentiation of the nucleus accumbens (NAc) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. However, in vivo parcellation of these structures in humans has been rare, potentially impairing future research into the structural and functional characteristics and alterations of putative NAc subregions. Here, we used three complementary parcellation schemes based on tractography, task-independent functional connectivity, and task-dependent co-activation to investigate the regional differentiation within the NAc. We found that a 2-cluster solution with shell-like and core-like subdivisions provided the best description of the data and was consistent with the earlier anatomical shell/core architecture. The consensus clusters from this optimal solution, which was based on the three schemes, were used as the final parcels for the subsequent connection analyses. The resulting connectivity patterns presented inter-hemispheric symmetry, convergence and divergence across the modalities, and, most importantly, clearly distinct patterns between the two subregions. This convergent connectivity patterns also confirmed the connections in animal models, supporting views that the two subregions could have antagonistic roles in some circumstances. Finally, the identified parcels should be helpful in further neuroimaging studies of the NAc.
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影响因子：
4.3
作者：
Baudonnat M;Huber A;David V;Walton ME
通讯作者：
Walton ME
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通讯作者：
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