Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder.
Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder.
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DOI：
10.1038/s41598-020-74239-x
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发表时间：
2020-10-15
影响因子：
4.6
通讯作者：
Pratesi CB
中科院分区：
文献类型：
--
作者：
Barbosa AG;Pratesi R;Paz GSC;Dos Santos MAAL;Uenishi RH;Nakano EY;Gandolfi L;Pratesi CB
在过去的几十年里，自闭症谱系障碍（ASD）有了显著的增加，这不能完全归因于更好的诊断和新病例交流的增加。ASD患者通常表现出与突触可塑性相关的蛋白质失调，特别是脑源性神经营养因子（BDNF）。本研究的目的是分析经典型自闭症儿童和健康对照组的BDNF血清浓度水平，以确定ASD和BDNF血清水平之间是否存在相关性。49名患有严重典型自闭症的儿童和37名健康儿童参加了这项研究。收集患者和对照组的血液样本，分析两组的BNDF水平。ASD患儿血清BDNF平均浓度水平高于对照组，差异有统计学意义（P < 0.000）。毫无疑问，BDNF在ASD发展和进化的病理生理中起着重要作用，但其在大脑中的水平可能会受到一些已知和未知因素的影响而波动。关键的问题不是BDNF水平是否可以被视为ASD的预后或诊断标志，而是确定其在这种疾病的发生和进展中的作用。
There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neurotrophic factor (BDNF). The objective of the present study was to analyze BDNF serum concentration levels in children with classic forms autism and a healthy control group to determine if there is a correlation between ASD and BDNF serum levels. Forty-nine children with severe classic form of autism, and 37 healthy children were enrolled in the study. Blood samples, from both patients and controls, were collected and BNDF levels from both groups were analyzed. The average BDNF serum concentration level was statistically higher for children with ASD (P < 0.000) compared to the control group. There is little doubt that BDNF plays a role in the pathophysiology of ASD development and evolution, but its brain levels may fluctuate depending on several known and unknown factors. The critical question is not if BDNF levels can be considered a prognostic or diagnostic marker of ASD, but to determine its role in the onset and progression of this disorder.
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