Association of Quadriceps Adiposity With an Increase in Knee Cartilage, Meniscus, or Bone Marrow Lesions Over Three Years.
Association of Quadriceps Adiposity With an Increase in Knee Cartilage, Meniscus, or Bone Marrow Lesions Over Three Years.
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DOI：
10.1002/acr.24232
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发表时间：
2021-08
影响因子：
4.7
通讯作者：
Souza RB
中科院分区：
文献类型：
--
作者：
Kumar D;Link TM;Jafarzadeh SR;LaValley MP;Majumdar S;Souza RB
评价膝关节骨关节炎（OA）患者3年内股四头肌和股内侧肌（VM）脂肪浸润与MRI显示膝关节软骨、半月板或骨髓病变（BML）增加的相关性。有和没有放射学膝关节OA的参与者（n=69）在基线和3年后接受了MRI。基于化学位移的水/脂肪MRI用于量化VM和整个四头肌的肌内脂肪分数和瘦解剖横截面积（阿克萨）。使用半定量改良蠕虫（m蠕虫）分级分析膝关节MRI图像，以评估关节软骨、半月板和BML病变的变化。使用逻辑回归评估基线四头肌和VM脂肪分数和瘦阿克萨是否与mWORMS评分增加相关。根据年龄、性别和BMI调整比值比（OR）。总体而言，62%（43/69）的受试者的软骨（26/43）、半月板（19/43）或BML（22/43）评分增加。股四头肌（或：2.13 [95%置信区间：1.09，4.15]）和VM（OR：2.05 [95%置信区间：1.25，3.36]）脂肪分数均与3年内软骨、半月板或BML评分增加相关。股四头肌或VM倾斜阿克萨与结果的相关性不显著。这些使用定量MRI方法评估肌肉肥胖的纵向结果突出了股四头肌肥胖，特别是VM在膝关节OA进展中的作用。然而，需要更大的队列研究来证实这些发现。
To evaluate the association of fatty infiltration of the quadriceps and vastus medialis (VM) with increase in knee cartilage, meniscus, or bone marrow lesions (BML) from MRI in knee osteoarthritis (OA) over 3-years. Participants (n=69) with and without radiographic knee OA underwent MRI at baseline and 3-years later. Chemical shift-based water/fat MRI were used to quantify the intramuscular fat fraction and the lean anatomical cross-sectional area (ACSA) for the VM and entire quadriceps muscles. MRI images of the knee were analyzed using semi-quantitative modified WORMS (mWORMS) grading to assess change in lesions in the articular cartilage, meniscus, and BML. Logistic regression was used to assess if baseline quadriceps and VM fat fraction and lean ACSA were associated with increase in mWORMS scores. Odds ratios (ORs) were adjusted for age, sex, and BMI. Overall 62% (43/69) of subjects had an increase in cartilage (26/43), meniscus (19/43), or BML (22/43) scores. Quadriceps (OR: 2.13 [95% confidence interval: 1.09, 4.15]) and VM (OR: 2.05 [95% confidence interval: 1.25, 3.36]) fat fraction were both associated with an increase in cartilage, meniscus, or BML scores over 3-years. The association of quadriceps or VM lean ACSA with the outcomes was not significant. These longitudinal findings using quantitative MRI methods for assessment of muscle adiposity highlight the role of quadriceps adiposity, specifically VM, in knee OA progression. However, studies in larger cohorts are needed to confirm these findings.
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影响因子：
3.4
作者：
de Almeida, Aline Castilho;Aily, Jessica Bianca;Mattiello, Stela Marcia
通讯作者：
Mattiello, Stela Marcia
影响因子：
3.3
作者：
Schick, F;Machann, J;Jacob, S
通讯作者：
Jacob, S
影响因子：
3.3
作者：
Reeder, SB;Pineda, AR;Pelc, NJ
通讯作者：
Pelc, NJ
影响因子：
7
作者：
Kumar, D.;Karampinos, D. C.;Souza, R. B.
通讯作者：
Souza, R. B.
影响因子：
3.5
作者：
Taaffe DR;Henwood TR;Nalls MA;Walker DG;Lang TF;Harris TB
通讯作者：
Harris TB