In vivo voltammetric studies on release mechanisms for cocaine with gamma-butyrolactone.
In vivo voltammetric studies on release mechanisms for cocaine with gamma-butyrolactone.
复制标题
DOI：
10.1016/0091-3057(91)90113-g
复制
发表时间：
1991-12
期刊：
影响因子：
--
通讯作者：
Broderick PA
中科院分区：
文献类型：
--
作者：
Broderick PA
本文研究了可卡因（20 mg/kg SC）对大鼠延髓核多巴胺（DA）和5-羟色胺（5-HT）突触前释放机制的影响。在神经冲动抑制剂γ-丁内酯（γ-BL）存在下，测定突触内DA和5-HT的浓度。结果与可卡因对自由活动大鼠多巴胺和5-羟色胺的影响进行了比较。神经化学时程曲线显示，γ-BL（35.8%）显著抑制多巴胺冲动流（p <0.0038）后，可卡因引起的多巴胺突触浓度的增加被显著阻断（p <0.0001）。神经化学时程曲线同时显示，γ-BL（50.6%）显著抑制（p <0.025）冲动流后，可卡因引起的突触内5-HT浓度的降低被显著阻断（p <0.0004）。研究结果表明，可卡因对多巴胺和羟色胺的突触浓度的影响依赖于神经冲动流。研究结果表明，突触前释放机制，这可能是不同的DA维斯5-HT，发挥作用的可卡因的作用机制。
The effect of cocaine (20 mg/kg SC) on presynaptic mechanisms of release for dopamine (DA) and for serotonin (5-HT) was studied in nucleus accumbens of unrestrained rats (Rattus norvegicus). The studies were done by assaying synaptic concentrations of DA and 5-HT in the presence of the neuronal impulse flow inhibitor, γ-butyrolactone (γ-BL). The results were compared with cocaine effects on accumbens DA and 5-HT in the freely moving rat, without γ-BL treatment. A neurochemical time course profile showed that the cocaine-induced increase in accumbens synaptic concentrations of DA was significantly blocked (p<0.0001) after DA impulse flow was significantly inhibited (p<0.0038) by γ-BL (35.8%). The neurochemical time course profile concurrently showed that the cocaine-induced decrease in accumbens synaptic concentrations of 5-HT was significantly blocked (p<0.0004) after impulse flow was significantly inhibited (p<0.025) by γ-BL (50.6%). The findings show that cocaine's effects on synaptic concentrations for DA and for HT in accumbens are dependent on neuronal impulse flow. The findings indicate that presynaptic releasing mechanisms, which may be different for DA vis-à-vis 5-HT, play a role in the mechanism of action of cocaine.
登录
查看更多内容
DOI：
10.1016/0091-3057(91)90112-f
发表时间：
1991-12
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Broderick PA
通讯作者：
Broderick PA
DOI：
10.1037/h0081662
发表时间：
1977-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
DEWIT, H;WISE, RA
通讯作者：
WISE, RA
影响因子：
3.3
作者：
CARBONI, E;IMPERATO, A;DICHIARA, G
通讯作者：
DICHIARA, G
影响因子：
6.1
作者：
PORRINO, LJ;RITZ, MC;GOLDBERG, SR
通讯作者：
GOLDBERG, SR
影响因子：
2.3
作者：
NOMIKOS, GG;DAMSMA, G;FIBIGER, HC
通讯作者：
FIBIGER, HC