Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men.
Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men.
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DOI：
10.1038/s41430-018-0242-7
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发表时间：
2019-05
影响因子：
4.7
通讯作者：
SESSA Research Group
中科院分区：
文献类型：
--
作者：
Sekikawa A;Mahajan H;Kadowaki S;Hisamatsu T;Miyagawa N;Fujiyoshi A;Kadota A;Maegawa H;Murata K;Miura K;Edmundowicz D;Ueshima H;SESSA Research Group
二十碳五烯酸（EPA）在日本的高风险群体中的临床试验显示，冠状动脉粥样硬化的进展较慢，日本的主要ω-3脂肪酸（OM 3）消费量远远高于其他国家。我们的目的是确定日本普通人群中冠状动脉钙化（CAC）和钙密度与OM 3、EPA和二十二碳六烯酸（DHA）（两种主要OM 3）的横截面关联。亚临床动脉粥样硬化的滋贺流行病学研究在2006-08年对1,074名年龄在40-79岁的男性进行了基于人群的样本检查，包括计算机断层扫描测量的CAC评分（CCS）、CAC密度评分（CDS）、血清OM 3水平和危险因素。CAC评分（CCS）是一种公认的冠状动脉粥样硬化生物标志物，CAC密度评分（CDS）是斑块稳定的潜在标志物。CCS >0、≥100和≥300的患病率分别为65.8%、25.9%和12.9%;平均（SD）OM 3、EPA和DHA分别为10.1%（3.2）、3.2%（1.7）和5.9%（1.6）。在有序逻辑回归中，CCS 0、100和300与OM 3、EPA和DHA增加1 SD相关的比值比（95% CI，p值）分别为0.91（0.81-1.03，p=0.12）、0.99（0.88-1.11，p=0.87）和0.84（0.74-0.94，p=<0.01）。在多变量校正模型中，DHA与CCS的负相关性仍然显著：比值比为0.87（0.77-0.99，p=0.03）。Om 3、EPA或DHA的血液水平与CDS没有任何显著相关性。在OM 3水平高的普通人群中，DHA而不是EPA与冠状动脉粥样硬化显著负相关。未来的试验需要比较高剂量DHA和EPA对动脉粥样硬化和心血管结局的影响。
Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1,074 men aged 40–79 in 2006–08 for computed-tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. Prevalence of CCS >0, ≥100, and ≥300 was 65.8%, 25.9% and 12.9%, respectively; the mean (SD) OM3, EPA and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100 and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81–1.03, p=0.12), 0.99 (0.88–1.11, p=0.87) and 0.84 (0.74–0.94, p=<0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77–0.99, p=0.03). Blood levels of OM3, EPA or DHA did not have any significant associations with CDS. DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes.
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影响因子：
2.8
作者：
Fujiyoshi A;Miura K;Kadowaki S;Azuma K;Tanaka S;Hisamatsu T;Arima H;Kadota A;Miyagawa N;Takashima N;Ohkubo T;Saitoh Y;Torii S;Miyazawa I;Maegawa H;Murata K;Ueshima H;SESSA Research Group
通讯作者：
SESSA Research Group
影响因子：
5.3
作者：
Cawood, Abbie L.;Ding, Ren;Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
37.8
作者：
Bild, DE;Detrano, R;Saad, MF
通讯作者：
Saad, MF
影响因子：
5.3
作者：
Mita, Tomoya;Watada, Hirotaka;Kawamori, Ryuzo
通讯作者：
Kawamori, Ryuzo
影响因子：
6.5
作者：
Erkkila, Arja T.;Matthan, Nirupa R.;Lichtenstein, Alice H.
通讯作者：
Lichtenstein, Alice H.