Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus.
Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus.
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DOI：
10.1177/0961203314555537
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发表时间：
2015-02
期刊：
影响因子：
2.6
通讯作者：
Brunner HI
中科院分区：
文献类型：
--
作者：
Mina R;Klein-Gitelman MS;Nelson S;Eberhard BA;Higgins G;Singer NG;Onel K;Tucker L;O'Neil KM;Punaro M;Levy DM;Haines K;Ying J;Brunner HI
评估肥胖对青少年型SLE（jSLE）健康相关生活质量（HRQOL）指标的影响。肥胖定义为根据疾病控制中心的性别-特异性体重指数-年龄图表确定的体重指数（BMI）≥ 95th%，并在jSLE患者的多中心队列中确定。在该次要分析中，将肥胖jSLE患者的儿科生活质量（PedsQL）量表和儿童健康问卷（CHQ）的领域和汇总评分与非肥胖jSLE患者以及既往肥胖和非肥胖健康对照进行比较。进行混合效应建模，以评估肥胖和HRQOL指标之间的关系。在202例jSLE患者中，25%（n=51）为肥胖。肥胖对jSLE患者的HRQOL有显著的负面影响，即使在调整了组间当前皮质类固醇使用、疾病活动、疾病损害、性别和种族的差异后。与非肥胖jSLE患者以及非肥胖和肥胖健康对照相比，肥胖jSLE患者的身体功能较低。与非肥胖患者相比，肥胖jSLE患者的学校功能更差，疼痛更多，社交功能和情感功能更差。肥胖jSLE患者的父母更担心。肥胖jSLE患者的CHQ评分在其他几个方面也比非肥胖jSLE患者差。我们的研究表明肥胖对jSLE患者报告的结局有不利影响。这支持了体重管理对jSLE治疗计划的重要性。
Evaluate the effects of obesity on health-related quality of life (HRQOL) measures in juvenile-onset SLE (jSLE). Obesity was defined as a body mass index (BMI) ≥ 95th% according to the sex-specific Center for Disease Control body mass index-for-age charts and determined in a multicenter cohort of jSLE patients. In this secondary analysis, the domain and summary scores of the Pediatric Quality of Life (PedsQL) Inventory and the Child Health Questionnaire (CHQ) of obese jSLE patients were compared to those of non-obese jSLE patients as well as historical obese and non-obese healthy controls. Mixed-effects modeling was performed to evaluate the relationship between obesity and HRQOL measures. Among the 202 jSLE patients, 25% (n=51) were obese. Obesity had a significant negative impact on HRQOL in jSLE, even after adjusting for differences in current corticosteroid use, disease activity, disease damage, gender, and race between groups. Obese jSLE patients had lower physical functioning compared to non-obese jSLE patients, and to non-obese and obese healthy controls. Compared to their non-obese counterparts, obese jSLE patients also had worse school functioning, more pain, worse social functioning, and emotional functioning. Parents of obese jSLE patients worry more. The CHQ scores for obese jSLE patients were also worse compared to non-obese jSLE patients in several other domains Our study demonstrates the detrimental effects of obesity on patient-reported outcomes in jSLE. This supports the importance of weight management for the therapeutic plan of jSLE.
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影响因子：
3.4
作者：
Chaiamnuay, Sumapa;Bertoli, Ana M.;Alarcon, Graciela S.
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
4.7
作者：
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通讯作者：
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