Estrogen Receptors Modulation of Anxiety-Like Behavior.
Estrogen Receptors Modulation of Anxiety-Like Behavior.
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DOI：
10.1016/bs.vh.2016.08.004
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发表时间：
2017
影响因子：
--
通讯作者：
Handa RJ
中科院分区：
文献类型：
--
作者：
Borrow AP;Handa RJ
雌激素对人类和啮齿动物的焦虑表达产生深远的影响;然而，这些影响的方向性在临床和临床前文献中有很大差异。据信，关于雌激素对焦虑的作用的性质的差异可归因于特定雌激素受体（ER）亚型的差异作用。在本章中，我们将讨论三种主要ER对焦虑和焦虑样行为的相对影响：ERα具有普遍的致焦虑作用，ERβ具有普遍的抗焦虑作用，G蛋白偶联ER GPR 30被发现既增加又减少焦虑样行为。此外，我们将描述这些受体亚型对情绪反应产生影响的已知机制，重点是下丘脑-垂体-肾上腺轴和催产素能和催产素能系统。雌激素对焦虑表达的影响可能是它们对所有这些神经生物学系统的综合作用的结果。
Estrogens exert profound effects on the expression of anxiety in humans and rodents; however, the directionality of these effects varies considerably within both clinical and preclinical literature. It is believed that discrepancies regarding the nature of estrogens’ effects on anxiety are attributable to the differential effects of specific estrogen receptor (ER) subtypes. In this chapter we will discuss the relative impact on anxiety and anxiety-like behavior of each of the three main ERs: ERα, which has a generally anxiogenic effect, ERβ, which has a generally anxiolytic effect, and the G-protein-coupled ER known as GPR30, which has been found to both increase and decrease anxiety-like behavior. In addition, we will describe the known mechanisms by which these receptor subtypes exert their influence on emotional responses, focusing on the hypothalamic–pituitary–adrenal axis and the oxytocinergic and serotonergic systems. The impact of estrogens on the expression of anxiety is likely the result of their combined effects on all of these neurobiological systems.
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