Glycosaminoglycanomic profiling of human milk in different stages of lactation by liquid chromatography-tandem mass spectrometry.
Glycosaminoglycanomic profiling of human milk in different stages of lactation by liquid chromatography-tandem mass spectrometry.
复制标题
通过液相色谱-串联质谱法对哺乳不同阶段的母乳进行糖胺聚糖分析。
DOI：
10.1016/j.foodchem.2018.03.076
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发表时间：
2018-08
期刊：
影响因子：
8.8
通讯作者：
Yu Guangli
中科院分区：
文献类型：
--
作者：
Wang Chen;Lang Yinzhi;Li Qinying;Jin Xin;Li Guoyun;Yu Guangli
人乳中的聚糖具有促进婴儿健康的几种重要生物学功能。糖胺聚糖（glycosaminoglycans, GAGs）是一类重要的多糖，是一个复杂的多阴离子碳水化合物家族，参与多种关键的生理和病理过程。本研究采用液相色谱-串联质谱联用技术，对不同哺乳期中国母亲母乳中gag的含量及详细组成进行了研究。结果表明，人乳样品中的GAG组分非常复杂，由硫酸肝素、硫酸软骨素和透明质酸组成。随着哺乳时间的延长，母乳中gag的总量逐渐减少。本研究对哺乳期不同阶段的GAGs需求具有重要的指导意义。研究结果对婴幼儿配方奶粉的组成和功能特性的研究也有一定的参考价值。
Glycans in human milk serve several important biological functions that promote infant health. As kind of important glycans, glycosaminoglycans (GAGs) are a complex family of polyanionic carbohydrate, participating in a variety of critical physiological and pathological processes. In this study, the content and the detailed composition of human milk GAGs from Chinese mothers in different stages of lactation, based on a liquid chromatography-tandem mass spectrometry approach was investigated. The results showed that the GAG fraction in the human milk samples was very complex as it was composed of heparan sulfate, chondroitin sulfate, and hyaluronic acid. With lactation extending, the total amount of GAGs in human milk decreased. This study provided an important guide for the demands of GAGs during different stages of lactation. The results were also beneficial for studies on the composition and functional properties of infant formula.
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DOI：
10.1093/ajcn/71.3.822
发表时间：
2000-03
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Ruth Morley;Alan Lucas
通讯作者：
Ruth Morley;Alan Lucas
DOI：
10.1089/bfm.2012.0052
发表时间：
2013-04
期刊：
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
影响因子：
--
作者：
G. Coppa;O. Gabrielli;L. Zampini;E. Bertino;N. Volpi
通讯作者：
G. Coppa;O. Gabrielli;L. Zampini;E. Bertino;N. Volpi
影响因子：
2.5
作者：
Rivero-Urgëll, M;Santamaría-Orleans, A
通讯作者：
Santamaría-Orleans, A
影响因子：
2.5
作者：
Coppa, Giovanni V.;Gabrielli, Orazio;Volpi, Nicola
通讯作者：
Volpi, Nicola
影响因子：
8.8
作者：
Tu, Anqi;Ma, Qiang;Du, Zhenxia
通讯作者：
Du, Zhenxia