Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014
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尿双酚 A 与儿童肥胖之间关联的系列横断面研究:使用 NHANES 2003-2014 年的最新更新

DOI:
10.1111/ijpo.12566
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发表时间:
2019
期刊:
影响因子:
3.8
通讯作者:
Belin Thomas
Belin Thomas
中科院分区:
医学3区
文献类型:
--
作者:
Okubo Yusuke;Handa Atsuhiko;Belin Thomas

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背景一些研究报道双酚A(BPA)是儿童肥胖的潜在危险因素,但这些研究的结果并不一致。方法使用2003年至2014年国家健康和营养检查调查的数据,我们进行了一系列横断面研究,以检查6岁和19岁儿童尿BPA与儿童肥胖之间的关联。使用多变量回归和三次样条模型拟合回归models.ResultsWe观察到尿BPA浓度从2003年至2014年下降的趋势,儿童肥胖和尿BPA浓度与或不与尿肌酐调整之间的关联进行了评估。在多年的调查中,即使使用了不同的尿肌酐调整模型,尿BPA浓度和肥胖之间的关联也不一致。肥胖儿童与尿肌酐浓度呈正相关,但与肌酐校正模型无关。此外,在2003年至2008年期间,尿BPA浓度较高的儿童患肥胖症的几率增加,而在2009年至2014年期间,这些相关性并不一致。需要进一步研究来评估这些差异。
BackgroundSeveral studies have reported bisphenol A (BPA) as a potential risk factor for paediatric obesity, but the findings were inconsistent among these studies.MethodsUsing data from the National Health and Nutrition Examination Survey from 2003 to 2014, we conducted a serial cross‐sectional study to examine the association between urinary BPA and paediatric obesity among children aged 6 and 19 years. The association between paediatric obesity and urinary BPA concentrations with or without urinary creatinine adjustments was assessed using multivariable regression and cubic spline models fitted for regression models.ResultsWe observed decreasing trends in urinary BPA concentrations from 2003 to 2014. The associations between urinary BPA concentrations and obesity were inconsistent across the years of survey and even after different models for urinary creatinine adjustments were used. Children with obesity were positively associated with urinary creatinine concentrations, but was not with creatinine‐adjusted models. Furthermore, children with higher urinary BPA concentrations had elevated odds of obesity during 2003 to 2008, whereas these associations were inconsistent during 2009 to 2014.ConclusionsThe associations between paediatric obesity and urinary BPA concentrations differed across the years of survey and creatinine adjustments. Further studies are required to assess these discrepancies.
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