Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014
Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014
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尿双酚 A 与儿童肥胖之间关联的系列横断面研究:使用 NHANES 2003-2014 年的最新更新
DOI:
10.1111/ijpo.12566
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发表时间:
2019
影响因子:
3.8
通讯作者:
Belin Thomas
中科院分区:
文献类型:
--
作者:
Okubo Yusuke;Handa Atsuhiko;Belin Thomas
BackgroundSeveral studies have reported bisphenol A (BPA) as a potential risk factor for paediatric obesity, but the findings were inconsistent among these studies.MethodsUsing data from the National Health and Nutrition Examination Survey from 2003 to 2014, we conducted a serial cross‐sectional study to examine the association between urinary BPA and paediatric obesity among children aged 6 and 19 years. The association between paediatric obesity and urinary BPA concentrations with or without urinary creatinine adjustments was assessed using multivariable regression and cubic spline models fitted for regression models.ResultsWe observed decreasing trends in urinary BPA concentrations from 2003 to 2014. The associations between urinary BPA concentrations and obesity were inconsistent across the years of survey and even after different models for urinary creatinine adjustments were used. Children with obesity were positively associated with urinary creatinine concentrations, but was not with creatinine‐adjusted models. Furthermore, children with higher urinary BPA concentrations had elevated odds of obesity during 2003 to 2008, whereas these associations were inconsistent during 2009 to 2014.ConclusionsThe associations between paediatric obesity and urinary BPA concentrations differed across the years of survey and creatinine adjustments. Further studies are required to assess these discrepancies.
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