Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth.
Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth.
复制标题
在怀孕和早产期间重复测量尿氧化应激生物标志物。
DOI：
10.1016/j.ajog.2014.08.007
复制
发表时间：
2015-02
影响因子：
9.8
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Ferguson, Kelly K.;McElrath, Thomas F.;Chen, Yin-Hsiu;Loch-Caruso, Rita;Mukherjee, Bhramar;Meeker, John D.
为了研究氧化应激作为人类早产的一种机制，我们检查了在怀孕期间的多个时间点测量的氧化应激尿生物标志物与早产之间的关系。这项嵌套病例对照研究包括130名早产母亲和352名足月分娩母亲，她们最初是作为布里格姆妇女医院正在进行的预期出生队列的一部分招募的。两个生物标志物，包括8-羟基脱氧鸟苷(8-OHdG)和8-异前列腺素，在妊娠期间最多四个时间点(中位数为10周、18周、26周和35周)采集的尿样中检测。随着妊娠的进展，8-异前列腺素和8-羟色胺的尿液浓度分别降低和升高。妊娠期间8-异前列腺素的平均水平与自发早产的几率增加有关(调整后的优势比[AOR]=6.25，95%可信区间[CI]=2.86，13.7)，且与妊娠后期测量的水平相关性最强。8-OHdG平均水平对总早产有保护作用(AOR=0.19，95%CI=0.10，0.34)，自然早产与胎盘源性早产的保护作用无明显差异。整体早产的优势比与怀孕早期测量的尿8-OHdG浓度相关，更具保护性。母亲的氧化应激可能是早产的一个重要因素，无论孕期暴露的亚型和时间如何。本研究中测量的两个生物标记物与早产存在相反的关联；对每一个标记物所代表的内容的更好理解可能有助于更准确地确定早产途径中的重要机制。
To investigate oxidative stress as a mechanism of preterm birth in human subjects, we examined associations between urinary biomarkers of oxidative stress measured at multiple time points during pregnancy and preterm birth. This nested case-control study included 130 mothers who delivered preterm and 352 who delivered term who were originally recruited as part of an ongoing prospective birth cohort at Brigham and Women’s Hospital. Two biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane were measured in urine samples collected at up to four time points (median 10, 18, 26, and 35 weeks) during gestation. Urinary concentrations of 8-isoprostane and 8-OHdG decreased and increased, respectively, as pregnancy progressed. Average levels of 8-isoprostane across pregnancy were associated with increased odds of spontaneous preterm birth (adjusted odds ratio [aOR]=6.25, 95% confidence interval [CI]=2.86, 13.7), and associations were strongest with levels measured later in pregnancy. Average levels of 8-OHdG were protective against overall preterm birth (aOR=0.19, 95%CI=0.10, 0.34), and there were no apparent differences in the protective effect in cases of spontaneous preterm birth compared to cases of placental origin. Odds ratios for overall preterm birth were more protective in association with urinary 8-OHdG concentrations measured early in pregnancy. Maternal oxidative stress may be an important contributor to preterm birth, regardless of subtype and timing of exposure during pregnancy. The two biomarkers measured in the present study had opposite associations with preterm birth; an improved understanding of what each represents may help to more precisely identify important mechanisms in the pathway to preterm birth.
登录
查看更多内容
影响因子：
3.3
作者：
Okamura, K;Doi, T;SugawaKatayama, Y
通讯作者：
SugawaKatayama, Y
影响因子：
3.3
作者：
Shoji, H;Franke, C;Koletzko, B
通讯作者：
Koletzko, B
影响因子：
7.2
作者：
Wei, Shu-Qin;Fraser, William;Luo, Zhong-Cheng
通讯作者：
Luo, Zhong-Cheng
影响因子：
2.9
作者：
Hsieh, T'sang-T'ang;Chen, Szu-Fu;Hung, Tai-Ho
通讯作者：
Hung, Tai-Ho
影响因子：
3.3
作者：
Stein, T. Peter;Scholl, Theresa O.;Rodriguez, Ana
通讯作者：
Rodriguez, Ana