Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders.
Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders.
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DOI：
10.1016/j.neulet.2013.02.017
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发表时间：
2013-04-29
影响因子：
2.5
通讯作者：
Hanna GL
中科院分区：
文献类型：
--
作者：
Carrasco M;Hong C;Nienhuis JK;Harbin SM;Fitzgerald KD;Gehring WJ;Hanna GL
错误相关负波（ERN）是在不正确的反应后事件相关电位的负向偏转，被认为反映了前扣带皮层（ACC）的活动，通常在焦虑症患者中增加。本研究测量了ERN和正确反应负性（CRN）在埃里克森侧翼任务，以评估性能监测在26个青年强迫症（OCD），13个青年与非强迫症焦虑症包括广泛性焦虑症或分离焦虑症，和27个年龄匹配的健康对照组，年龄从8岁到16岁。与健康对照组相比，强迫症或非强迫症焦虑症患者的ERN振幅显著增加。CRN振幅无显著组间差异。用β-肾上腺素能抗抑郁药或认知行为疗法治疗对患者的ERN没有影响。所有受试者的儿童行为量表DSM导向焦虑问题量表得分与ERN振幅显著相关。结果提供了进一步的证据，强迫症和一些非强迫症焦虑症的病理生理学涉及ACC活性增加，ERN可能作为这些复杂性状的遗传和纵向研究的定量表型。
The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is thought to reflect activity in the anterior cingulate cortex (ACC) and is often increased in patients with anxiety disorders. This study measured the ERN and correct response negativity (CRN) during an Eriksen flanker task to assess performance monitoring in 26 youth with obsessive-compulsive disorder (OCD), 13 youth with a non-OCD anxiety disorder consisting of either generalized anxiety disorder or separation anxiety disorder, and 27 age-matched healthy controls ranging in age from 8 to 16 years. Compared to healthy controls, ERN amplitude was significantly increased in patients with either OCD or a non-OCD anxiety disorder. There were no significant group differences in CRN amplitude. Treatment with a serotonergic antidepressant or cognitive-behavior therapy had no effect on the ERN in patients. Scores from the Child Behavior Checklist DSM-oriented anxiety problems scale had a significant correlation with ERN amplitude in all subjects. The results provide further evidence that the pathophysiology of OCD and some non-OCD anxiety disorders involves increased ACC activity and that the ERN may serve as a quantitative phenotype in genetic and longitudinal studies of these complex traits.
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影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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