Longitudinal prospective study examining the effects of the timing of prenatal stress on infant and child regulatory functioning: the Michigan Prenatal Stress Study protocol.
Longitudinal prospective study examining the effects of the timing of prenatal stress on infant and child regulatory functioning: the Michigan Prenatal Stress Study protocol.
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DOI：
10.1136/bmjopen-2021-054964
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发表时间：
2021-09-17
期刊：
影响因子：
2.9
通讯作者：
Nuttall AK
中科院分区：
文献类型：
--
作者：
Levendosky AA;Bogat GA;Lonstein J;Muzik M;Nuttall AK
大量文献表明，产前压力是儿童期及以后心理功能不良的关键决定因素。然而，关于产前应激的时间是否对儿童结局（包括精神病理学）的发展产生不同影响的知识实际上尚不清楚。我们研究的主要目的是研究产前应激的时间如何不同地影响幼儿期的调节功能，作为精神病理学的标志。我们的第二个目的是研究妊娠期间母亲生理和心理因素的中介作用。我们的第三个目标是研究产后因素对儿童调节功能的调节作用。我们的项目是第一个解决这些问题的纵向、前瞻性、多方法研究。我们正在进行的研究招募孕妇，对亲密伴侣暴力（一种常见的基于事件的压力源，允许检查时间效应）进行过采样，数据收集从怀孕第 15 周开始，到产后 4 年结束。我们的目标是拥有 n=335 母子二人组。我们对妊娠压力进行精细评估（每周根据产妇报告进行测量），以揭示胎儿生命中的敏感时期，此时压力特别会破坏以后的功能。基于模式的统计分析将用于识别怀孕期间压力时间不同的女性亚组，然后测试这些压力模式是否可以差异预测幼儿期的自我调节结果。由于我们样本的高风险性质，我们会采取谨慎措施确保他们的健康受到保护，包括针对自杀意念的安全计划和保护参与者数据隐私的安全机制（在线每周调查中的退出按钮）。这项研究得到了密歇根州立大学机构审查委员会的批准。传播将通过国家儿童健康和人类发展数据和样本中心 (DASH) 研究所的数据共享以及通过在行为神经内分泌学到临床和发展心理学的期刊上发表研究结果来进行。
A considerable literature implicates prenatal stress as a critical determinant of poor psychological functioning in childhood and beyond. However, knowledge about whether the timing of prenatal stress differentially influences the development of child outcomes, including psychopathology, is virtually unknown. The primary aim of our study is to examine how the timing of prenatal stress differentially affects early childhood regulatory functioning as a marker of psychopathology. Our second aim is to examine the mediating effects of maternal physiological and psychological factors during pregnancy. Our third aim is to examine the moderating effects of postnatal factors on child regulatory functioning. Our project is the first longitudinal, prospective, multimethod study addressing these questions. Our ongoing study recruits pregnant women, oversampled for intimate partner violence (a common event-based stressor allowing examination of timing effects), with data collection starting at pregnancy week 15 and concluding 4 years post partum. We aim to have n=335 mother–child dyads. We conduct a granular assessment of pregnancy stress (measured weekly by maternal report) in order to reveal sensitive periods during fetal life when stress particularly derails later functioning. Pattern-based statistical analyses will be used to identify subgroups of women who differ in the timing of their stress during pregnancy and then test whether these patterns of stress differentially predict early childhood self-regulatory outcomes. Due to the high-risk nature of our sample, care is taken to ensure protection of their well-being, including a safety plan for suicidal ideation and a safety mechanism (exit button in the online weekly survey) to protect participant data privacy. This study was approved by Michigan State University Institutional Review Board. Dissemination will be handled by data sharing through National Institute of Child Health and Human Development Data and Specimen Hub (DASH), as well as through publishing the findings in journals spanning behavioural neuroendocrinology to clinical and developmental psychology.
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