Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures.
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures.
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DOI：
10.1210/er.2016-1083
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发表时间：
2016-12
影响因子：
20.3
通讯作者：
Hardie LJ
中科院分区：
文献类型：
--
作者：
Potter GD;Skene DJ;Arendt J;Cade JE;Grant PJ;Hardie LJ
昼夜节律（~ 24小时）定时系统遍及所有生命王国，并在时间上优化人类的行为和生理。我们环境的相对近期的变化，比如人工照明的引入，可以扰乱昼夜节律系统，从调节细胞活动时间的分子钟水平到我们日常行为周期与太阳日之间的同步水平。睡眠/觉醒周期与昼夜节律系统交织在一起，全球趋势表明，这些周期也越来越容易受到干扰。世界上很大一部分人口面临着环境驱动的昼夜节律和睡眠中断的风险增加，少数人也有昼夜节律失调和睡眠障碍的遗传倾向。昼夜节律系统和睡眠中断的后果是深远的，包括无数的代谢后果，其中一些可能会因饮食选择的不利影响而加剧。如果不加以处理，这种干扰的有害影响将继续造成广泛的健康问题；因此，许多行为和药物干预的实施可以帮助恢复昼夜节律系统的一致性和提高睡眠将是重要的。
Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important.
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影响因子：
8.2
作者：
Below, J. E.;Gamazon, E. R.;Morrison, J. V.;Konkashbaev, A.;Pluzhnikov, A.;McKeigue, P. M.;Parra, E. J.;Elbein, S. C.;Hallman, D. M.;Nicolae, D. L.;Bell, G. I.;Cruz, M.;Cox, N. J.;Hanis, C. L.
通讯作者：
Hanis, C. L.
DOI：
10.1007/s00420-003-0482-1
发表时间：
2004-02-01
影响因子：
3
作者：
Axelsson, J;Åkerstedt, T;Lowden, A
通讯作者：
Lowden, A
DOI：
10.1152/ajpregu.00397.2003
发表时间：
2004-06-01
影响因子：
2.8
作者：
Barger, LK;Wright, KP;Czeisler, CA
通讯作者：
Czeisler, CA
影响因子：
3.2
作者：
Amstrup, Anne Kristine;Sikjaer, Tanja;Rejnmark, Lars
通讯作者：
Rejnmark, Lars
影响因子：
5.6
作者：
Bertisch, Suzanne M.;Sillau, Stefan;Redline, Susan
通讯作者：
Redline, Susan