Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.
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DOI：
10.1289/ehp.10700
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发表时间：
2008-03
影响因子：
10.4
通讯作者：
INUENDO
中科院分区：
文献类型：
--
作者：
Bonde JP;Toft G;Rylander L;Rignell-Hydbom A;Giwercman A;Spano M;Manicardi GC;Bizzaro D;Ludwicki JK;Zvyezday V;Bonefeld-Jørgensen EC;Pedersen HS;Jönsson BA;Thulstrup AM;INUENDO
我们综合了一项关于生物持久性有机污染物（POP）对人类生殖功能影响的国际流行病学研究的主要结果。我们使用了一个数据库，其中包含2，269名女性及其配偶的访谈和生物学数据，以及18篇已发表的核心论文。该研究没有提供多氯联苯（PCB）同系物CB-153和主要的二氯二苯基三氯乙烷（DDT）代谢物1，1-二氯-2，2-双（对氯苯基）乙烯（p，p′-DDE）具有类似于大麻活性的直接证据，因为这些化合物的血清浓度与血清中的内源性或外源性激素活性并不总是相关。然而，持久性有机污染物接触与男性生殖功能的生物标志物之间存在着若干联系。首先，在雄激素受体CAG重复长度短的男性亚组中检测到高CB-153血清水平和低精子计数之间的关联。其次，在所有四个研究区域中均观察到CB-153血清浓度升高与精子活力降低之间的关系，精浆中中性α-葡萄糖苷酶活性降低的迹象表明存在睾丸后效应。第三，精子染色质完整性的损害是相当少的频率在格陵兰因纽特人相比，在欧洲组，只有在后者是精子染色质完整性的损害与持久性有机污染物。尽管存在这些影响，但除因纽特人外，就受孕时间而言，生育率与持久性有机污染物无关。对后者的可能解释尚未确定。持久性有机污染物可能干扰男性生殖功能，但对生育能力没有重大影响。这些数据没有提供内分泌干扰的直接证据，因此还应考虑其他机制。
We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p′-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral α-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified. POPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered.
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DOI：
10.1016/0890-6238(88)90023-8
发表时间：
1988-01-01
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Baird, D D
通讯作者：
Baird, D D
影响因子：
3.3
作者：
Dandevi, K;Rozati, R;Grover, P
通讯作者：
Grover, P
影响因子：
8.8
作者：
Hsu, PC;Guo, YLL;Li, MH
通讯作者：
Li, MH
影响因子：
6.1
作者：
Axmon, A;Thulstrup, AM;Hagmar, L
通讯作者：
Hagmar, L
影响因子：
6.1
作者：
Carlsen, E;Swan, SH;Skakkebæk, NE
通讯作者：
Skakkebæk, NE